Rei Aoki Takeo Saito Kohei Ninomiya Ayu Shimasaki Takuma Ashizawa Kenta Ito Masashi Ikeda Nakao Iwata
Psychiatry and clinical neurosciences 76(8) 361-366 2022年5月
AIM: The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets. METHODS: We used two data s...
Yunfeng Ruan Yen-Feng Lin Yen-Chen Anne Feng Chia-Yen Chen Max Lam Zhenglin Guo Yong Min Ahn Kazufumi Akiyama Makoto Arai Ji Hyun Baek Wei J. Chen Young-Chul Chung Gang Feng Kumiko Fujii Stephen J. Glatt Kyooseob Ha Kotaro Hattori Teruhiko Higuchi Akitoyo Hishimoto Kyung Sue Hong Yasue Horiuchi Hai-Gwo Hwu Masashi Ikeda Sayuri Ishiwata Masanari Itokawa Nakao Iwata Eun-Jeong Joo Rene S. Kahn Sung-Wan Kim Se Joo Kim Se Hyun Kim Makoto Kinoshita Hiroshi Kunugi Agung Kusumawardhani Jimmy Lee Byung Dae Lee Heon-Jeong Lee Jianjun Liu Ruize Liu Xiancang Ma Woojae Myung Shusuke Numata Tetsuro Ohmori Ikuo Otsuka Yuji Ozeki Sibylle G. Schwab Wenzhao Shi Kazutaka Shimoda Kang Sim Ichiro Sora Jinsong Tang Tomoko Toyota Ming Tsuang Dieter B. Wildenauer Hong-Hee Won Takeo Yoshikawa Alice Zheng Feng Zhu Lin He Akira Sawa Alicia R. Martin Shengying Qin Hailiang Huang Tian Ge
Nature Genetics 54(5) 573-580 2022年5月 [査読有り]
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduce...
The amygdala is a prominent region of the brain that plays a critical role in the pathophysiology of major depressive disorder (MDD). The amygdala is formed from a collection of interconnected substructures (nuclei) that relay signals from multipl...
Vassily Trubetskoy Antonio F Pardiñas Ting Qi Georgia Panagiotaropoulou Swapnil Awasthi Tim B Bigdeli Julien Bryois Chia-Yen Chen Charlotte A Dennison Lynsey S Hall Max Lam Kyoko Watanabe Oleksandr Frei Tian Ge Janet C Harwood Frank Koopmans Sigurdur Magnusson Alexander L Richards Julia Sidorenko Yang Wu Jian Zeng Jakob Grove Minsoo Kim Zhiqiang Li Georgios Voloudakis Wen Zhang Mark Adams Ingrid Agartz Elizabeth G Atkinson Esben Agerbo Mariam Al Eissa Margot Albus Madeline Alexander Behrooz Z Alizadeh Köksal Alptekin Thomas D Als Farooq Amin Volker Arolt Manuel Arrojo Lavinia Athanasiu Maria Helena Azevedo Silviu A Bacanu Nicholas J Bass Martin Begemann Richard A Belliveau Judit Bene Beben Benyamin Sarah E Bergen Giuseppe Blasi Julio Bobes Stefano Bonassi Alice Braun Rodrigo Affonseca Bressan Evelyn J Bromet Richard Bruggeman Peter F Buckley Randy L Buckner Jonas Bybjerg-Grauholm Wiepke Cahn Murray J Cairns Monica E Calkins Vaughan J Carr David Castle Stanley V Catts Kimberley D Chambert Raymond C K Chan Boris Chaumette Wei Cheng Eric F C Cheung Siow Ann Chong David Cohen Angèle Consoli Quirino Cordeiro Javier Costas Charles Curtis Michael Davidson Kenneth L Davis Lieuwe de Haan Franziska Degenhardt Lynn E DeLisi Ditte Demontis Faith Dickerson Dimitris Dikeos Timothy Dinan Srdjan Djurovic Jubao Duan Giuseppe Ducci Frank Dudbridge Johan G Eriksson Lourdes Fañanás Stephen V Faraone Alessia Fiorentino Andreas Forstner Josef Frank Nelson B Freimer Menachem Fromer Alessandra Frustaci Ary Gadelha Giulio Genovese Elliot S Gershon Marianna Giannitelli Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Javier González Peñas Ana González-Pinto Srihari Gopal Jacob Gratten Michael F Green Tiffany A Greenwood Olivier Guillin Sinan Gülöksüz Raquel E Gur Ruben C Gur Blanca Gutiérrez Eric Hahn Hakon Hakonarson Vahram Haroutunian Annette M Hartmann Carol Harvey Caroline Hayward Frans A Henskens Stefan Herms Per Hoffmann Daniel P Howrigan Masashi Ikeda Conrad Iyegbe Inge Joa Antonio Julià Anna K Kähler Tony Kam-Thong Yoichiro Kamatani Sena Karachanak-Yankova Oussama Kebir Matthew C Keller Brian J Kelly Andrey Khrunin Sung-Wan Kim Janis Klovins Nikolay Kondratiev Bettina Konte Julia Kraft Michiaki Kubo Vaidutis Kučinskas Zita Ausrele Kučinskiene Agung Kusumawardhani Hana Kuzelova-Ptackova Stefano Landi Laura C Lazzeroni Phil H Lee Sophie E Legge Douglas S Lehrer Rebecca Lencer Bernard Lerer Miaoxin Li Jeffrey Lieberman Gregory A Light Svetlana Limborska Chih-Min Liu Jouko Lönnqvist Carmel M Loughland Jan Lubinski Jurjen J Luykx Amy Lynham Milan Macek Jr Andrew Mackinnon Patrik K E Magnusson Brion S Maher Wolfgang Maier Dolores Malaspina Jacques Mallet Stephen R Marder Sara Marsal Alicia R Martin Lourdes Martorell Manuel Mattheisen Robert W McCarley Colm McDonald John J McGrath Helena Medeiros Sandra Meier Bela Melegh Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Marina Mitjans Espen Molden Esther Molina María Dolores Molto Valeria Mondelli Carmen Moreno Christopher P Morley Gerard Muntané Kieran C Murphy Inez Myin-Germeys Igor Nenadić Gerald Nestadt Liene Nikitina-Zake Cristiano Noto Keith H Nuechterlein Niamh Louise O'Brien F Anthony O'Neill Sang-Yun Oh Ann Olincy Vanessa Kiyomi Ota Christos Pantelis George N Papadimitriou Mara Parellada Tiina Paunio Renata Pellegrino Sathish Periyasamy Diana O Perkins Bruno Pfuhlmann Olli Pietiläinen Jonathan Pimm David Porteous John Powell Diego Quattrone Digby Quested Allen D Radant Antonio Rampino Mark H Rapaport Anna Rautanen Abraham Reichenberg Cheryl Roe Joshua L Roffman Julian Roth Matthias Rothermundt Bart P F Rutten Safaa Saker-Delye Veikko Salomaa Julio Sanjuan Marcos Leite Santoro Adam Savitz Ulrich Schall Rodney J Scott Larry J Seidman Sally Isabel Sharp Jianxin Shi Larry J Siever Engilbert Sigurdsson Kang Sim Nora Skarabis Petr Slominsky Hon-Cheong So Janet L Sobell Erik Söderman Helen J Stain Nils Eiel Steen Agnes A Steixner-Kumar Elisabeth Stögmann William S Stone Richard E Straub Fabian Streit Eric Strengman T Scott Stroup Mythily Subramaniam Catherine A Sugar Jaana Suvisaari Dragan M Svrakic Neal R Swerdlow Jin P Szatkiewicz Thi Minh Tam Ta Atsushi Takahashi Chikashi Terao Florence Thibaut Draga Toncheva Paul A Tooney Silvia Torretta Sarah Tosato Gian Battista Tura Bruce I Turetsky Alp Üçok Arne Vaaler Therese van Amelsvoort Ruud van Winkel Juha Veijola John Waddington Henrik Walter Anna Waterreus Bradley T Webb Mark Weiser Nigel M Williams Stephanie H Witt Brandon K Wormley Jing Qin Wu Zhida Xu Robert Yolken Clement C Zai Wei Zhou Feng Zhu Fritz Zimprich Eşref Cem Atbaşoğlu Muhammad Ayub Christian Benner Alessandro Bertolino Donald W Black Nicholas J Bray Gerome Breen Nancy G Buccola William F Byerley Wei J Chen C Robert Cloninger Benedicto Crespo-Facorro Gary Donohoe Robert Freedman Cherrie Galletly Michael J Gandal Massimo Gennarelli David M Hougaard Hai-Gwo Hwu Assen V Jablensky Steven A McCarroll Jennifer L Moran Ole Mors Preben B Mortensen Bertram Müller-Myhsok Amanda L Neil Merete Nordentoft Michele T Pato Tracey L Petryshen Matti Pirinen Ann E Pulver Thomas G Schulze Jeremy M Silverman Jordan W Smoller Eli A Stahl Debby W Tsuang Elisabet Vilella Shi-Heng Wang Shuhua Xu Rolf Adolfsson Celso Arango Bernhard T Baune Sintia Iole Belangero Anders D Børglum David Braff Elvira Bramon Joseph D Buxbaum Dominique Campion Jorge A Cervilla Sven Cichon David A Collier Aiden Corvin David Curtis Marta Di Forti Enrico Domenici Hannelore Ehrenreich Valentina Escott-Price Tõnu Esko Ayman H Fanous Anna Gareeva Micha Gawlik Pablo V Gejman Michael Gill Stephen J Glatt Vera Golimbet Kyung Sue Hong Christina M Hultman Steven E Hyman Nakao Iwata Erik G Jönsson René S Kahn James L Kennedy Elza Khusnutdinova George Kirov James A Knowles Marie-Odile Krebs Claudine Laurent-Levinson Jimmy Lee Todd Lencz Douglas F Levinson Qingqin S Li Jianjun Liu Anil K Malhotra Dheeraj Malhotra Andrew McIntosh Andrew McQuillin Paulo R Menezes Vera A Morgan Derek W Morris Bryan J Mowry Robin M Murray Vishwajit Nimgaonkar Markus M Nöthen Roel A Ophoff Sara A Paciga Aarno Palotie Carlos N Pato Shengying Qin Marcella Rietschel Brien P Riley Margarita Rivera Dan Rujescu Meram C Saka Alan R Sanders Sibylle G Schwab Alessandro Serretti Pak C Sham Yongyong Shi David St Clair Hreinn Stefánsson Kari Stefansson Ming T Tsuang Jim van Os Marquis P Vawter Daniel R Weinberger Thomas Werge Dieter B Wildenauer Xin Yu Weihua Yue Peter A Holmans Andrew J Pocklington Panos Roussos Evangelos Vassos Matthijs Verhage Peter M Visscher Jian Yang Danielle Posthuma Ole A Andreassen Kenneth S Kendler Michael J Owen Naomi R Wray Mark J Daly Hailiang Huang Benjamin M Neale Patrick F Sullivan Stephan Ripke James T R Walters Michael C O'Donovan
Nature 604(7906) 502-508 2022年4月
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common ...
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