研究者氏名	西辻裕紀
	ニシツジヒロノリ
通称等の別名	藤田医科大学
URL
所属	藤田医科大学
部署	ウイルス学
職名	准教授
科研費研究者番号	20573661
J-Global ID	201801009029607414

研究分野

ライフサイエンス / ウイルス学 /

論文

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A new hepatoma cell line exhibiting high susceptibility to hepatitis B virus infection.

Youki Ueda Weilin Gu Hiromichi Dansako Hironori Nishitsuji Shinya Satoh Kunitada Shimotohno Nobuyuki Kato

Biochemical and biophysical research communications 515(1) 156-162 2019年7月 [査読有り]

Hepatitis B virus (HBV) infection, which increases the risk of cirrhosis and hepatocellular carcinoma and requires lifelong treatment, has become a major global health problem. However, host factors essential to the HBV life cycle are still unclea...

Multiple antiviral activities of the antimalarial and anti-hepatitis C drug candidates N-89 and N-251.

Youki Ueda Weilin Gu Hiromichi Dansako Hye-Sook Kim Sayaka Yoshizaki Nobuaki Okumura Tomohiro Ishikawa Hironori Nishitsuji Fumihiro Kato Takayuki Hishiki Shinya Satoh Koji Ishii Michiaki Masuda Kunitada Shimotohno Masanori Ikeda Nobuyuki Kato

Biochemistry and biophysics reports 15 1-6 2018年9月 [査読有り]

The chemically synthesized endoperoxide compound N-89 and its derivative N-251 were shown to have potent antimalarial activity. We previously demonstrated that N-89 and N-251 potently inhibited the RNA replication of hepatitis C virus (HCV), which...

Serum miRNAs Predicting Sustained HBs Antigen Reduction 48 Weeks after Pegylated Interferon Therapy in HBe Antigen-Negative Patients.

Koji Fujita Shima Mimura Hisakazu Iwama Mai Nakahara Kyoko Oura Tomoko Tadokoro Takako Nomura Joji Tani Hirohito Yoneyama Asahiro Morishita Makoto Oryu Takashi Himoto Hironori Nishitsuji Kunitada Shimotohno Masao Omata Tsutomu Masaki

International journal of molecular sciences 19(7) 2018年7月 [査読有り]

The therapeutic goal for hepatitis B virus (HBV) infection is HBs antigen (HBsAg) seroclearance, which is achieved through 48-week pegylated interferon (Peg-IFN) therapy. This study aimed to identify predictive biomarkers for sustained HBsAg reduc...

Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide.

Kei Miyakawa Satoko Matsunaga Yutaro Yamaoka Mina Dairaku Kento Fukano Hirokazu Kimura Tomoyuki Chimuro Hironori Nishitsuji Koichi Watashi Kunitada Shimotohno Takaji Wakita Akihide Ryo

Oncotarget 9(34) 23681-23694 2018年5月 [査読有り]

Sodium taurocholate cotransporting polypeptide (NTCP) is a major entry receptor of hepatitis B virus (HBV) and one of the most attractive targets for anti-HBV drugs. We developed a cell-mediated drug screening method to monitor NTCP expression on ...

TIP60 Complex Inhibits Hepatitis B Virus Transcription.

Hironori Nishitsuji Saneyuki Ujino Keisuke Harada Kunitada Shimotohno

Journal of virology 92(6) 2018年3月 [査読有り]

Hepatitis B virus (HBV) is a global major health problem, with over one million deaths annually caused by chronic liver damage. Understanding host factors that modulate HBV replication may aid the development of anti-HBV therapies. Our recent geno...