研究者氏名	西辻裕紀
	ニシツジヒロノリ
通称等の別名	藤田医科大学
URL
所属	藤田医科大学
部署	ウイルス学
職名	准教授
科研費研究者番号	20573661
J-Global ID	201801009029607414

研究分野

ライフサイエンス / ウイルス学 /

論文

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Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.

Shun Kaneko Sei Kakinuma Yasuhiro Asahina Akihide Kamiya Masato Miyoshi Tomoyuki Tsunoda Sayuri Nitta Yu Asano Hiroko Nagata Satoshi Otani Fukiko Kawai-Kitahata Miyako Murakawa Yasuhiro Itsui Mina Nakagawa Seishin Azuma Hiromitsu Nakauchi Hironori Nishitsuji Saneyuki Ujino Kunitada Shimotohno Masashi Iwamoto Koichi Watashi Takaji Wakita Mamoru Watanabe

Scientific reports 6 29358-29358 2016年7月 [査読有り]

Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of HBV covalently closed circular DNA (cccDNA) in host cells, and thus development of novel culture models for productive HBV infection is urgently needed,...

ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor κ Light Chain Enhancer of Activated B Cells (NF-κB) Activation by BST-2.

Hironori Nishitsuji Ryuichi Sugiyama Makoto Abe Hiroshi Takaku

The Journal of biological chemistry 291(9) 4754-62 2016年2月 [査読有り]

Here, we identify ATP1B3 and fibrillin-1 as novel BST-2-binding proteins. ATP1B3 depletion in HeLa cells (BST-2-positive cells), but not 293T cells (BST-2-negative cells), induced the restriction of HIV-1 production in a BST-2-dependent manner. In...

Hepatitis C virus utilizes VLDLR as a novel entry pathway.

Saneyuki Ujino Hironori Nishitsuji Takayuki Hishiki Kazuo Sugiyama Hiroshi Takaku Kunitada Shimotohno

Proceedings of the National Academy of Sciences of the United States of America 113(1) 188-93 2016年1月 [査読有り]

Various host factors are involved in the cellular entry of hepatitis C virus (HCV). In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Cultur...

Lipid and lipoprotein components play important roles the egress and infectivity of hepatitis C virions

Takayuki Hishiki Yuko Shimizu Saneyuki Ujino Hironori Nishitsuji Kunitada Shimotohno

Hepatitis C Virus I: Cellular and Molecular Virology 255-272 2016年1月 [査読有り]

Persistent hepatitis C virus (HCV) infection is a leading cause of liver diseases, including chronic hepatitis C, progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic hepatitis C is strongly associated with lipid accumulati...

Novel reporter system to monitor early stages of the hepatitis B virus life cycle.

Hironori Nishitsuji Saneyuki Ujino Yuko Shimizu Keisuke Harada Jing Zhang Masaya Sugiyama Masashi Mizokami Kunitada Shimotohno

Cancer science 106(11) 1616-24 2015年11月 [査読有り]

A recombinant hepatitis B virus (HBV) expressing NanoLuc (NL) (HBV/NL) was produced by cotransfecting a plasmid containing a 1.2-fold HBV genome carrying the NL gene with a plasmid bearing a packaging-defective 1.2-fold HBV genome into a human hep...