Jun Okada   Nobuko Ohshima   Ritsuko Kubota-Koketsu   Sayuri Ota   Wakana Takase   Masachika Azuma   Yoshitaka Iba   Naoko Nakagawa   Tetsushi Yoshikawa   Youichi Nakajima   Toyokazu Ishikawa   Yoshizo Asano   Yoshinobu Okuno   Yoshikazu Kurosawa   
VIROLOGY 397(2) 322-330 2010年2月 [査読有り]
We tried to reveal the strain specificity of neutralizing mAbs against H3N2 influenza viruses in individuals. A large number of B lymphocytes of a pediatrician were collected by apheresis and two Ab libraries were constructed at 2004 and 2007 by u...
JOURNAL OF IMMUNOLOGICAL METHODS 351(1-2) 1-12 2009年12月 [査読有り]
In order to isolate monoclonal antibodies (mAbs) that bind to tumor-associated antigens (Ags) we developed the following strategy. Using the phage-display Ab library we isolated a large number of mAbs that bind to the surface of human tumor cells....
MICROBES AND INFECTION 11(13) 1029-1036 2009年11月 [査読有り]
Human antibodies specific for HCMV are currently considered as potential anti-HCMV therapeutic agents. In this study, we used it combinatorial human antibody library to isolate and characterize complete human monoclonal antibodies that effectively...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 383(4) 480-484 2009年6月 [査読有り]
We reported comprehensive screening for antigens (Ags) overexpressed on various carcinomas via isolation of human monoclonal antibodies (mAbs) that may be therapeutic in a previous paper (Proc. Natl. Acad. Sci. USA 105, 7287-7292, 2008). Twenty-on...
JOURNAL OF VIROLOGY 83(4) 2020-2024 2009年2月 [査読有り]
Varicella-zoster virus (VZV) glycoprotein H (gH) is the major neutralization target of VZV, and its neutralizing epitope is conformational. Ten neutralizing human monoclonal antibodies to gH were used to map the epitopes by immunohistochemical ana...