To suppress virus multiplication, infected macrophages produce NO. However, it remains unclear how infecting viruses then overcome NO challenge. In the present study, we report the effects of accessory protein C from Sendai virus (SeV), a prototyp...
The effect of TGF-β1 on CpG DNA-induced type I IFN production was examined by reconstituting a series of signaling molecules in TLR 3 signaling. TGF-β1 inhibited CpG DNA-induced IFN-α4 productivity in HeLa cells. Transfection of IFN regulatory fac...
Here we report that LPS induces osteoclast (OC) formation in murine RAW 264.7 macrophage cells in RPMI-1640 medium but not in α-minimum essential medium (α-MEM) as the original culture medium. LPS-induced OC formation in both media was examined to...
Naoki Koide   Erdenezaya Odkhuu   Yoshikazu Naiki   Bilegtsaikhan Tsolmongyn   Kiyoaki Ito   Takayuki Komatsu   Tomoaki Yoshida   Takashi Yokochi   
Innate immunity 20(8) 816-25 2014年11月 [査読有り]
The effect of LPS on the production of vascular endothelial growth factor (VEGF) was examined using RAW 264.7 macrophage cells. LPS induced VEGF production in RAW 264.7 cells and mouse peritoneal cells. LPS induced VEGF production via the expressi...
International immunopharmacology 20(1) 181-7 2014年5月 [査読有り]
The inhibitory effect of valproic acid (VPA) on lipopolysaccharide (LPS)-induced inflammatory response was studied by using mouse RAW 264.7 macrophage-like cells. VPA pretreatment attenuated LPS-induced phosphorylation of phosphatidylinositol 3-ki...
T Sugiyama   N Kido   Y Kato   N Koide   T Yoshida   T Yokochi   
JOURNAL OF BACTERIOLOGY 180(10) 2775-2778 1998年5月
Genetic characterization of the wb* gene in a series of Escherichia coli and Klebsiella strains possessing the mannose homopolymer as the O-specific polysaccharide was carried out. The partial nucleotide sequences and PCR-restriction fragment leng...
T Sugiyama   N Kido   Y Kato   N Koide   T Yoshida   T Yokochi   
GENE 198(1-2) 111-113 1997年10月
In order to clarify the evolutionary relationship among rfb gene clusters synthesizing mannose homopolymer as O-specific polysaccharides in Escherichia coli and Klebsiella, we studied the DNA sequence of the boundary region between the rfb and his...