研究者氏名	鈴木元

URL	http://info.fujita-hu.ac.jp/~motosuzu/index.html
所属	藤田医科大学
部署	医学部医学科
職名	教授
学位	医学博士(名古屋大学)
J-Global ID	200901026349208170

研究分野

ライフサイエンス / 呼吸器内科学 /
ライフサイエンス / 腫瘍生物学 /

論文

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Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas.

Naomi Gondo Yasuhiro Sakai Zhenhuan Zhang Yukari Hato Kiyotaka Kuzushima Suchada Phimsen Yoshiaki Kawashima Makoto Kuroda Motoshi Suzuki Seiji Okada Hiroji Iwata Tatsuya Toyama Andri Rezano Kazuhiko Kuwahara

Laboratory investigation; a journal of technical methods and pathology 101(8) 1048-1059 2021年8月

Breast cancer, the most common malignancy among women, is closely associated with mutations in the tumor suppressor gene BRCA. DSS1, a component of the TRanscription-EXport-2 (TREX-2) complex involved in transcription and mRNA nuclear export, stab...

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.

Hanxiao Shi Atsuko Niimi Toshiyuki Takeuchi Kazuya Shiogama Yasuyoshi Mizutani Taisuke Kajino Kenichi Inada Tetsunari Hase Takahiro Hatta Hirofumi Shibata Takayuki Fukui Toyofumi Fengshi Chen-Yoshikawa Kazuki Nagano Takashi Murate Yoshiyuki Kawamoto Shuta Tomida Takashi Takahashi Motoshi Suzuki

Cancer science 112(7) 2770-2780 2021年7月

Ceramide synthase 6 (CERS6) promotes lung cancer metastasis by stimulating cancer cell migration. To examine the underlying mechanisms, we performed luciferase analysis of the CERS6 promoter region and identified the Y-box as a cis-acting element....

Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator

Hisanori Isomura Ayumu Taguchi Taisuke Kajino Naoya Asai Masahiro Nakatochi Seiichi Kato Keiko Suzuki Kiyoshi Yanagisawa Motoshi Suzuki Teruaki Fujishita Tomoya Yamaguchi Masahide Takahashi Takashi Takahashi

Cancer Science 112(4) 1614-1623 2021年4月

We previously reported that ROR1 is a crucial downstream gene for the TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indica...

Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.

Behnoush Khaledian Ayumu Taguchi Kazuo Shin-Ya Lisa Kondo-Ida Noritaka Kagaya Motoshi Suzuki Taisuke Kajino Tomoya Yamaguchi Yukako Shimada Takashi Takahashi

Cancer science 112(3) 1225-1234 2021年3月

We have previously identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a direct transcriptional target of TTF-1/NKX2-1, a lineage-survival oncogene in lung adenocarcinoma. ROR1 sustains prosurvival signaling from multiple receptor...

Upregulation of S100A10 in metastasized breast cancer stem cells.

Hisano Yanagi Takashi Watanabe Tatsunori Nishimura Takanori Hayashi Seiji Okada Motoshi Suzuki Hironobu Minami Akira Suzuki Kenji Kawada Noriko Gotoh Yohei Shimono

CANCER SCIENCE 112 705-705 2021年2月