研究者氏名	鈴木元

URL	http://info.fujita-hu.ac.jp/~motosuzu/index.html
所属	藤田医科大学
部署	医学部医学科
職名	教授
学位	医学博士(名古屋大学)
J-Global ID	200901026349208170

研究分野

ライフサイエンス / 呼吸器内科学 /
ライフサイエンス / 腫瘍生物学 /

論文

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CERS6 required for cell migration and metastasis in lung cancer.

Motoshi Suzuki Ke Cao Seiichi Kato Naoki Mizutani Kouji Tanaka Chinatsu Arima Mei Chee Tai Norie Nakatani Kiyoshi Yanagisawa Toshiyuki Takeuchi Hanxiao Shi Yasuyoshi Mizutani Atsuko Niimi Tetsuo Taniguchi Takayuki Fukui Kohei Yokoi Keiko Wakahara Yoshinori Hasegawa Yukiko Mizutani Soichiro Iwaki Satoshi Fujii Akira Satou Keiko Tamiya-Koizumi Takashi Murate Mamoru Kyogashima Shuta Tomida Takashi Takahashi

Journal of cellular and molecular medicine 24(20) 11949-11959 2020年9月 [査読有り]

Sphingolipids constitute a class of bio-reactive molecules that transmit signals and exhibit a variety of physical properties in various cell types, though their functions in cancer pathogenesis have yet to be elucidated. Analyses of gene expressi...

Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.

Chisato Inoue Sayaka Sobue Yoshiyuki Kawamoto Yuji Nishizawa Masatoshi Ichihara Akihiro Abe Fumihiko Hayakawa Motoshi Suzuki Yoshinori Nozawa Takahsi Murate

Biochemical and biophysical research communications 525(4) 1074-1080 2020年5月 [査読有り]

T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive to ponatinib (PNT). However, the novel strategy i...

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.

Chisato Inoue Sayaka Sobue Naoki Mizutani Yoshiyuki Kawamoto Yuji Nishizawa Masatoshi Ichihara Toshiyuki Takeuchi Fumihiko Hayakawa Motoshi Suzuki Tetsuro Ito Yoshinori Nozawa Takashi Murate

Nagoya journal of medical science 82(2) 261-280 2020年5月 [査読有り]

Resveratrol (RSV) has recently attracted keen interest because of its pleiotropic effects. It exerts a wide range of health-promoting effects. In addition to health-promoting effects, RSV possesses anti-carcinogenic activity. However, a non-physio...

A Novel Cytological Model of B-Cell/Macrophage Biphenotypic Cell Hodgkin Lymphoma in Ganp-Transgenic Mice.

Yasuhiro Sakai Andri Rezano Seiji Okada Takahiro Ohtsuki Yoshiaki Kawashima Tetsuya Tsukamoto Motoshi Suzuki Michinori Kohara Motohiro Takeya Nobuo Sakaguchi Kazuhiko Kuwahara

Cancers 12(1) 2020年1月 [査読有り]

Hodgkin lymphoma (HL) is one of the most difficult neoplasms in terms of cytopathological research owing to the lack of established cytological murine models. Although HL is believed to be of lymphoid germinal center B-cell origin, HL cells exhibi...

Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7–positive prostate cancer cells

Atsuhiko Yoshizawa Kiyoshi Takahara Masanobu Saruta Kenji Zennami Takuhisa Nukaya Kosuke Fukaya Manabu Ichino Naohiko Fukami Atsuko Niimi Hitomi Sasaki Mamoru Kusaka Motoshi Suzuki Makoto Sumitomo Ryoichi Shiroki

Prostate International 2020年

© 2020 Background: Disease progression in castrate-resistant prostate cancer (PCa) is most commonly driven by the reactivation of androgen receptor (AR) signaling and involves AR splice variants including ARV7. Materials and methods: We used the A...