Z. Liu K. Yanagisawa S. Griesing M. Iwai K. Kano N. Hotta T. Kajino M. Suzuki T. Takahashi
ONCOGENE 36(26) 3740-3748 2017年6月
TTF-1, also known as NKX2-1, is a transcription factor that has indispensable roles in both lung development and physiology. We and others have reported that TTF-1 frequently exhibits high expression with increased copy number in lung adenocarcino...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 486(2) 551-557 2017年4月
Taxoids are anti-cancer drugs frequently used to treat solid tumors, but they are sometimes ineffective and tumors may become resistant to their action. Here, we examined the involvement of sphingolipid metabolic enzymes in paclitaxel (PTX) resist...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 479(4) 808-813 2016年10月
Paclitaxel (PTX) is a microtubule-targeting drug widely used for the treatment of a variety of cancers. However, drug resistance can emerge after a series of treatments, and this can seriously affect the patient's prognosis. Here, we analyzed the ...
Lisa Ida Tomoya Yamaguchi Kiyoshi Yanagisawa Taisuke Kajino Yukako Shimada Motoshi Suzuki Takashi Takahashi
CANCER SCIENCE 107(2) 155-161 2016年2月
We previously identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a transcriptional target of the NKX2-1/TTF-1 lineage-survival oncogene in lung adenocarcinoma. ROR1 consequently sustains a favorable balance between pro-survival p...
お知らせ・マニュアル
医学部