J Hamako T Matsui S Nishida S Nomura Y Fujimura M Ito Y Ozeki K Titani
THROMBOSIS AND HAEMOSTASIS 80(3) 499-505 1998年9月 [査読有り]
A von Willebrand factor (vWF)-binding and -cleaving metalloproteinase, termed "kaouthiagin", was purified from the venom of cobra snake Naja kaouthia. Kaouthiagin is a monomer with a molecular mass of about 46 kDa and 51 kDa under non-reducing and...
T Matsui S Kunishima J Hamako M Katayama T Kamiya T Naoe Y Ozeki Y Fujimura K Titani
JOURNAL OF BIOCHEMISTRY 121(2) 376-381 1997年2月 [査読有り]
The binding of human von Willebrand factor (vWF) to a variety of extracellular matrix components immobilized on plates and the binding of vWF to platelet glycoprotein It, (GPIb) after interacting with these matrix components mere examined by means...
J Hamako T Matsui M Suzuki M Ito K Makita Y Fujimura Y Ozeki K Titani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 226(1) 273-279 1996年9月 [査読有り]
We have screened 20 snake venoms and purified a novel snake venom protein, named bitiscetin, from Bitis arietans venom that specifically binds to human von Willebrand factor (vWF) and induces platelet agglutination. Bitiscetin showed a heterodimer...
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