Naoki Yahata   Yuji Matsumoto   Minoru Omi   Naoki Yamamoto   Ryuji Hata   
SCIENTIFIC REPORTS 7(1) 15557 2017年11月 [査読有り]
Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke...
JOURNAL OF ALZHEIMERS DISEASE 51(4) 997-1002 2016年 [査読有り]
As a proof of concept that removal of blood amyloid-beta (A beta) can reduce A beta deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes A beta from the blood, were ...
Masahiro Sakanaka   Pengxiang Zhu   Bo Zhang   Tong-Chun Wen   Fang Cao   Yong-Jie Ma   Keiichi Samukawa   Noriaki Mitsuda   Junya Tanaka   Makoto Kuramoto   Hidemitsu Uno   Ryuji Hatai   
JOURNAL OF NEUROTRAUMA 24(6) 1037-1054 2007年6月 [査読有り]
Red ginseng root (Panax Ginseng CA Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. One of the major components of Red ginseng root is ginsenoside Rb-1 (gRb1). Previously, we showed that ...
The effects of transient cochlear ischemia on spiral ganglion cells (SGCs) were studied in Mongolian gerbils. Ischemic insult was induced by occluding the bilateral vertebral arteries of gerbils for 15 min. Seven days after ischemia, the percentag...
Taro Takagi   Tadashi Yoshida   Masahiro Okada   Ryuji Hata   Naohito Hato   Kiyofumi Gyo   Nobuhiro Hakuba   
NEUROREPORT 25(11) 807-813 2014年8月 [査読有り]
Bone marrow mononuclear cells (BMMCs) are known to enhance recovery from ischemic insults by secreting angiogenic factors and inducing the expression of angiogenic factors from host tissues. Therefore, the transplantation of BMMCs is considered a ...
Oligomeric forms of amyloid-beta peptide (A beta) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from famil...
Pengxiang Zhu   Ryuji Hata   Masahito Ogasawara   Fang Cao   Kenji Kameda   Kohei Yamauchi   Alfred H. Schinkel   Kazutaka Maeyama   Masahiro Sakanaka   
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 32(10) 1897-1908 2012年10月 [査読有り]
The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because in...
Naomi Sonobe   Ryuji Hata   Tomohisa Ishikawa   Kantaro Sonobe   Teruhisa Matsumoto   Yasutaka Toyota   Takaaki Mori   Ryuji Fukuhara   Kenjiro Komori   Shu-ichi Ueno   Satoshi Tanimukai   Manabu Ikeda   
INTERNATIONAL PSYCHOGERIATRICS 23(5) 772-779 2011年6月 [査読有り]
Background: Memory impairment has been proposed as the most common early sign of Alzheimer's disease (AD). The aims of this work were to evaluate the risk of progression from mild memory impairment / no dementia (MMI/ND) to clinically diagnos...
Akihiko Taguchi   Pengxiang Zhu   Fang Cao   Akie Kikuchi-Taura   Yukiko Kasahara   David M. Stern   Toshihiro Soma   Tomohiro Matsuyama   Ryuji Hata   
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 31(3) 855-867 2011年3月 [査読有り]
Circulating bone marrow-derived immature cells, including endothelial progenitor cells, have been implicated in homeostasis of the microvasculature. Decreased levels of circulating endothelial progenitor cells, associated with aging and/or cardiov...