M Iwai HW Liu R Chen A Ide S Okamoto R Hata M Sakanaka T Shiuchi M Horiuchi
CIRCULATION 110(7) 843-848 2004年8月 [査読有り]
Background-The role of angiotensin II receptor subtypes was investigated in focal brain ischemia induced by middle cerebral artery (MCA) occlusion.
Methods and Results-In Agtr2(+) (wild-type) mice, MCA occlusion induced focal ischemia of approxima...
F Gu R Hata K Toku LH Yang YJ Ma N Maeda M Sakanaka J Tanaka
JOURNAL OF NEUROSCIENCE RESEARCH 72(6) 709-715 2003年6月 [査読有り]
Aquaporin-4 (AQP4) is located on astrocyte endfeet that face blood vessels in the brain and in the pia. It is thought to play a crucial role in the development of brain edema. To confirm the notion that sex steroids and dexamethasone influence bra...
TC Wen Y Sadamoto J Tanaka PX Zhu K Nakata YJ Ma R Hata M Sakanaka
JOURNAL OF NEUROSCIENCE RESEARCH 67(6) 795-803 2002年3月 [査読有り]
Erythropoietin (EPO) promotes neuronal survival after cerebral ischemia in vivo and after hypoxia in vitro. However, the mechanisms underlying the protective effects of EPO on ischemic/hypoxic neurons are not fully understood. The present in vitro...
K Heese T Nakayama R Hata M Masumura H Akatsu F Li Y Nagai T Yamamoto K Kosaka T Suemoto T Sawada
EUROPEAN JOURNAL OF NEUROSCIENCE 15(1) 79-86 2002年1月 [査読有り]
The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains, Here we describe a new protein, CGI-94, ...
Taro Takagi Tadashi Yoshida Masahiro Okada Ryuji Hata Naohito Hato Kiyofumi Gyo Nobuhiro Hakuba
NEUROREPORT 25(11) 807-813 2014年8月 [査読有り]
Bone marrow mononuclear cells (BMMCs) are known to enhance recovery from ischemic insults by secreting angiogenic factors and inducing the expression of angiogenic factors from host tissues. Therefore, the transplantation of BMMCs is considered a ...
Oligomeric forms of amyloid-beta peptide (A beta) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from famil...
Pengxiang Zhu Ryuji Hata Masahito Ogasawara Fang Cao Kenji Kameda Kohei Yamauchi Alfred H. Schinkel Kazutaka Maeyama Masahiro Sakanaka
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 32(10) 1897-1908 2012年10月 [査読有り]
The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because in...
Naomi Sonobe Ryuji Hata Tomohisa Ishikawa Kantaro Sonobe Teruhisa Matsumoto Yasutaka Toyota Takaaki Mori Ryuji Fukuhara Kenjiro Komori Shu-ichi Ueno Satoshi Tanimukai Manabu Ikeda
INTERNATIONAL PSYCHOGERIATRICS 23(5) 772-779 2011年6月 [査読有り]
Background: Memory impairment has been proposed as the most common early sign of Alzheimer's disease (AD). The aims of this work were to evaluate the risk of progression from mild memory impairment / no dementia (MMI/ND) to clinically diagnos...
Akihiko Taguchi Pengxiang Zhu Fang Cao Akie Kikuchi-Taura Yukiko Kasahara David M. Stern Toshihiro Soma Tomohiro Matsuyama Ryuji Hata
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 31(3) 855-867 2011年3月 [査読有り]
Circulating bone marrow-derived immature cells, including endothelial progenitor cells, have been implicated in homeostasis of the microvasculature. Decreased levels of circulating endothelial progenitor cells, associated with aging and/or cardiov...
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