OBJECTIVE: In order to provide regenerative therapy for millions of patients suffering from corneal blindness globally, we derived corneal endothelial cell substitute (CECSi) cells from induced pluripotent stem cells (iPSCs) to treat corneal edema...
Anandalakshmi V   Hochart G   Bonnel D   Stauber J   Shimmura S   Lakshminarayanan R   Pervushin K   Mehta J.S   
Separations 8(7) 2021年7月
Stromal corneal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene. The mutant TGFBIp is prone to protein aggregation and the mutant protein gets deposited in the cornea, leading to severe visual impairment. The ...
Robert Maximilian Rusch   Yoko Ogawa   Shinri Sato   Satoru Morikawa   Emi Inagaki   Eisuke Shimizu   Kazuo Tsubota   Shigeto Shimmura   
International journal of molecular sciences 22(9) 2021年5月
Mesenchymal stem cells (MSCs) have been widely used in therapeutic applications for many decades. However, more and more evidence suggests that factors such as the site of origin and pre-implantation treatment have a crucial impact on the result. ...
Corneal epithelial stem cells reside in the limbal area between the cornea and conjunctiva. We examined the potential use of limbal organoids as a source of transplantable limbal stem cells. After treating tissue with collagenase, limbal cells wer...