Objectives. To explore the effectiveness and safety of tocilizumab (TCZ) with or without methotrexate (MTX) in active rheumatoid arthritis (RA) patients showing inadequate responses to DMARDs and/or TNF inhibitors in clinical practice.Methods. We ...
Tanaka Y   Kubo S   Yamanaka H   Amano K   Hirata S   Tanaka E   Nagasawa H   Yasuoka H   Takeuchi T   
Hidekata Yasuoka   Yukie Yamaguchi   Carol A. Feghali-Bostwick   
PLOS ONE 9(2) e87754 2014年2月 [査読有り]
Systemic sclerosis (SSc) is characterized by excessive fibrosis of the skin and internal organs due to fibroblast proliferation and excessive production of extracellular matrix (ECM). We have shown that insulin-like growth factor binding protein (...
Arthritis and Rheumatism 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class 1 chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
ARTHRITIS AND RHEUMATISM 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
BRITISH JOURNAL OF HAEMATOLOGY 124(6) 796-801 2004年3月
Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were examined in 84 adult Japanese patients with chronic immune thrombocytopenic purpura (ITP) and 56 race-matched healthy controls. The SNPs examined were within the genes enco...