Modern Rheumatology 23(6) 1211-1220 2013年11月 [査読有り]
Objective: To assess the efficacy of epoprostenol treatment in Japanese patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD). Methods: Sixteen patients with PAH-CTD treated with continuous intravenous...
Keiko Aida-Yasuoka   Christine Peoples   Hidekata Yasuoka   Pamela Hershberger   Katelynn Thiel   Jane A. Cauley   Thomas A. Medsger   Carol A. Feghali-Bostwick   
ARTHRITIS RESEARCH & THERAPY 15(1) R10 2013年 [査読有り]
Introduction: Systemic sclerosis (SSc) is more prevalent in women. Our goal is to determine the effects of 17 beta-estradiol (E2) on the development of fibrosis and to compare circulating levels of estrogens in SSc patients and healthy controls.
M...
ARTHRITIS RESEARCH & THERAPY 15(4) R74 2013年 [査読有り]
Introduction: Altered phenotypes of circulating monocytes of patients with systemic sclerosis (SSc) have been reported, but the role of these alterations in the pathogenesis of SSc remains unclear. This study was undertaken to identify molecules t...
Objective. To clarify the characteristics, survival and predictors of mortality in Japanese patients with pulmonary arterial hypertension (PAH) associated with CTD.
Methods. This single-centre cohort study enrolled 70 consecutive patients with PAH...
Yukie Yamaguchi   Hidekata Yasuoka   Donna B. Stolz   Carol A. Feghali-Bostwick   
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 15(4) 957-969 2011年4月 [査読有り]
Our previous studies have demonstrated increased expression of insulin-like growth factor binding protein-5 (IGFBP-5) in fibrotic tissues and IGFBP-5 induction of extracellular matrix (ECM) components. The mechanism resulting in increased IGFBP-5 ...
Arthritis and Rheumatism 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class 1 chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
ARTHRITIS AND RHEUMATISM 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
BRITISH JOURNAL OF HAEMATOLOGY 124(6) 796-801 2004年3月
Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were examined in 84 adult Japanese patients with chronic immune thrombocytopenic purpura (ITP) and 56 race-matched healthy controls. The SNPs examined were within the genes enco...