研究者氏名	安岡秀剛
	ヤスオカヒデカタ
URL
所属	藤田医科大学
部署	医学部・リウマチ・膠原病内科学
職名	教授
学位	博士（医学）(慶應義塾大学)
J-Global ID	200901028124352037

研究キーワード

アレルギー性疾患 ,免疫性疾患 ,allergic diseases ,Immunologic diseases

研究分野

ライフサイエンス / 膠原病、アレルギー内科学 /
ライフサイエンス / 免疫学 /

経歴

藤田医科大学医学部リウマチ・膠原病内科学教授

学歴

2003年

慶應義塾大学大学院医学研究科内科学専攻（リウマチ）

2003年

慶應義塾大学

1997年

慶應義塾大学医学部医学科

1997年

慶應義塾大学

論文

<6 789 10 >

Role of Insulin-like Growth Factor Binding Protein-3 in Allergic Airway Remodeling

Kristen L. Veraldi Bethany T. Gibson Hidekata Yasuoka Michael M. Myerburg Elizabeth A. Kelly Silvana Balzar Nizar N. Jarjour Joseph M. Pilewski Sally E. Wenzel Carol A. Feghali-Bostwick

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180(7) 611-617 2009年10月 [査読有り]

Rationale. The hallmarks of allergic asthma are airway inflammation, obstruction, and remodeling. Airway remodeling may lead to irreversible airflow obstruction with increased morbidity and mortality. Despite advances in the treatment of asthma, t...

The Pro-Fibrotic Factor IGFBP-5 Induces Lung Fibroblast and Mononuclear Cell Migration

Hidekata Yasuoka Yukie Yamaguchi Carol A. Feghali-Bostwick

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 41(2) 179-188 2009年8月 [査読有り]

We have previously shown that insulin-like growth factor-binding protein-5 (IGFBP-5) is overexpressed in fibrotic lung tissues and that it induces production of extracellular matrix components such as Collagen and fibronectin both in vitro and in ...

The Fibrotic Phenotype Induced by IGFBP-5 Is Regulated by MAPK Activation and Egr-1-Dependent and -Independent Mechanisms

Hidekata Yasuoka Eileen Hsu Ximena D. Ruiz Richard A. Steinman Augustine M. K. Choi Carol A. Feghali-Bostwick

AMERICAN JOURNAL OF PATHOLOGY 175(2) 605-615 2009年8月 [査読有り]

We have previously shown that insulin-like growth factor (IGF) binding protein-5 (IGFBP-5) is overexpressed in lung fibrosis and induces the production of extracellular matrix components, such as collagen and fibronectin, both in vitro and in vivo...

Gene expression in pulmonary fibrosis

Eileen Hsu Hidekata Yasuoka Carol A. Feghali-Bostwick

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 18(1) 47-56 2008年 [査読有り]

Pulmonary fibrosis is a phenotype that results from a variety of conditions and is associated with significant morbidity and mortality. Ongoing research in the field is driven by the need for effective treatments for pulmonary fibrosis. In this re...

Human skin culture as an ex vivo model for assessing the fibrotic effects of insulin-like growth factor binding proteins.

Hidekata Yasuoka Adriana T Larregina Yukie Yamaguchi Carol A Feghali-Bostwick

The open rheumatology journal 2 17-22 2008年 [査読有り]

Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology. A hallmark of SSc is fibrosis of the skin and internal organs. We recently demonstrated increased expression of IGFBP-3 and IGFBP-5 in primary cultures of fibroblasts fro...

MISC

12 3 4 5 >

Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behçet's disease

Hidekata Yasuoka Yuka Okazaki Yutaka Kawakami Michito Hirakata Hidetoshi Inoko Yasuo Ikeda Masataka Kuwana

Arthritis and Rheumatism 50(11) 3658-3662 2004年11月

Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class 1 chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...

Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behcet's disease

H Yasuoka Y Okazaki Y Kawakami M Hirakata H Inoko Y Ikeda M Kuwana

ARTHRITIS AND RHEUMATISM 50(11) 3658-3662 2004年11月

Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...

Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura

T Satoh JP Pandey Y Okazaki H Yasuoka Y Kawakami Y Ikeda M Kuwana

BRITISH JOURNAL OF HAEMATOLOGY 124(6) 796-801 2004年3月

Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were examined in 84 adult Japanese patients with chronic immune thrombocytopenic purpura (ITP) and 56 race-matched healthy controls. The SNPs examined were within the genes enco...

多発性筋炎・皮膚筋炎(PM/DM)の新たな自己抗体Profileに関する研究

第48回日本リウマチ学会総会 2004年

赤芽球癆を合併した抗Ku抗体陽性の全身性エリテマトーデス(SLE)の一例

第48回日本リウマチ学会総会 2004年