Systemic sclerosis (SSc) is characterized by excessive fibrosis and autoantibody production. However, the pathogenesis of SSc is still under investigation. We have demonstrated that a novel testicular antigen, protein highly expressed in testis (P...
Hidekata Yasuoka Zhihong Zhou Joseph M. Pilewski Tim D. Oury Augustine M. K. Choi Carol A. Feghali-Bostwick
AMERICAN JOURNAL OF PATHOLOGY 169(5) 1633-1642 2006年11月 [査読有り]
We have recently shown that insulin-like growth factor-binding protein (IGFBP)-5 is overexpressed in idiopathic pulmonary fibrosis lung tissues and increases collagen and fibronectin deposition. Here, we further examined the effect of IGFBP-5 in v...
Hidekata Yasuoka Drazen M. Jukic Zhihong Zhou Augustine M. K. Choi Carol A. Feghali-Bostwick
ARTHRITIS AND RHEUMATISM 54(9) 3001-3010 2006年9月 [査読有り]
Objective. To determine the role of insulin-like growth factor binding protein 5 (IGFBP-5) in the development of skin fibrosis in vivo, by examining the effect of overexpression of IGFBP-5 in mouse skin.
Methods. Wild-type C57BL/6J mice were injec...
M Kuwana J Kaburaki Y Okazaki H Yasuoka Y Kawakami Y Ikeda
ARTHRITIS AND RHEUMATISM 54(6) 1946-1951 2006年6月 [査読有り]
Objective. To evaluate whether atorvastatin can increase bone marrow-derived circulating endothelial precursors (CEPs) and improve the vascular symptoms in patients with systemic sclerosis (SSc; scleroderma).
Methods. The study was designed as an ...
S Suzuki T Satoh H Yasuoka Y Hamaguchi K Tanaka Y Kawakami N Suzuki M Kuwana
JOURNAL OF NEUROIMMUNOLOGY 170(1-2) 141-149 2005年12月 [査読有り]
Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyos...
Arthritis and Rheumatism 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class 1 chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
H Yasuoka Y Okazaki Y Kawakami M Hirakata H Inoko Y Ikeda M Kuwana
ARTHRITIS AND RHEUMATISM 50(11) 3658-3662 2004年11月
Objective. To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Be...
T Satoh JP Pandey Y Okazaki H Yasuoka Y Kawakami Y Ikeda M Kuwana
BRITISH JOURNAL OF HAEMATOLOGY 124(6) 796-801 2004年3月
Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were examined in 84 adult Japanese patients with chronic immune thrombocytopenic purpura (ITP) and 56 race-matched healthy controls. The SNPs examined were within the genes enco...
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