(6R)-l-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Sp...
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18(4) 312-317 2011年 [査読有り]
Aims: Cilostazol, a type. phosphodiesterase inhibitor, is utilized for the treatment of intermittent claudication and is considered to have the beneficial effects against the atherogenic process. In the present study, we examined the effects of ci...
JOURNAL OF BIOLOGICAL CHEMISTRY 286(2) 1445-1452 2011年1月 [査読有り]
Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor....
JOURNAL OF PHARMACOLOGICAL SCIENCES 114(1) 17-24 2010年9月 [査読有り]
5R-L-Erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa's disease) was revealed to be caused by dominant mutations of the gene e...
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1780(7-8) 960-965 2008年7月 [査読有り]
2,4-Diamino-6-hydroxypyrimidine (DAHP) is considered a specific inhibitor of BH4 biosynthesis and is widely used in order to elucidate the possible biological function of BH4 in various cells. In the present study, we found that both the synthesis...
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