研究者氏名	浅井直也
	アサイナオヤ
所属	藤田医科大学
部署	医学部病理学講座
職名	教授
学位	博士（医学）(名古屋大学)
J-Global ID	200901070978348285

研究キーワード

遺伝子改変マウスの作製と解析

研究分野

ライフサイエンス / 実験病理学 /

経歴

2019年4月

現在

藤田医科大学医学部病理学講座教授

2009年4月

2019年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター先端応用医学部門准教授

論文

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Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.

Ryota Ando Yukihiro Shiraki Yuki Miyai Hiroki Shimizu Kazuhiro Furuhashi Shun Minatoguchi Katsuhiro Kato Akira Kato Tadashi Iida Yasuyuki Mizutani Kisuke Ito Naoya Asai Shinji Mii Nobutoshi Esaki Masahide Takahashi Atsushi Enomoto

The Journal of pathology 2023年10月

Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...

脂肪細胞分泌因子アディプシンの喪失による乳がんの浸潤・転移の抑制(Lack of adipokine adipsin suppresses breast cancer invasion and metastasis)

林孝典吉田淳平宗綱栄二 Behnoush Khaledian 前田真男水野真広牛田かおり河田健司浅井直也下野洋平

日本癌学会総会記事 82回 978-978 2023年9月

アディプシン依存的な脂肪細胞分化は脂肪細胞と乳がん幹細胞の相互作用を増進する(Adipsin-dependent adipocyte differentiation promotes the adipocyte-breast cancer stem cell interactions)

Khaledian Behnoush 吉田淳平林孝典水野真広牛田かおり前田真男宗綱栄二河田健司浅井直也下野洋平 Shimono Yohei

日本癌学会総会記事 82回 1349-1349 2023年9月

Effect of eribulin on epithelial-mesenchymal transition plasticity in metastatic breast cancer: An exploratory, prospective study.

Takanori Hayashi Naomi Kobayashi Kaori Ushida Naoya Asai Shogo Nakano Kimihito Fujii Takahito Ando Toshiaki Utsumi

Genes to cells : devoted to molecular & cellular mechanisms 2023年2月 [査読有り]

Epithelial-mesenchymal transition (EMT) plays a pivotal role in cancer metastasis and treatment resistance, which worsens prognosis. In phase III trials, eribulin improved overall survival in metastatic breast cancer (MBC) patients. In preclinical...

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

Shun Minatoguchi Shoji Saito Kazuhiro Furuhashi Yuriko Sawa Masaki Okazaki Yuko Shimamura Ahmad Baseer Kaihan Yusaku Hashimoto Yoshinari Yasuda Akitoshi Hara Yasuyuki Mizutani Ryota Ando Noritoshi Kato Takuji Ishimoto Naotake Tsuboi Nobutoshi Esaki Makoto Matsuyama Yukihiro Shiraki Hiroki Kobayashi Naoya Asai Atsushi Enomoto Shoichi Maruyama

Scientific Reports 12(1) 2022年12月

Abstract

Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute to chronic kidney disease progression. Several PMC markers have been identified; however, PMC heterogeneity and functions are not...

MISC

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Deficiency of CD109, a negative regulator of TGF-beta signaling, leads epidermal hyperplasia and appendage abnormalities in mice

Shinji Mii Yoshiki Murakumo Naoya Asai Masato Asai Masahide Takahashi

CANCER RESEARCH 72 2012年4月

Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.

Nobutaka Ohgami Michiru Ida-Eto Naomi Sakashita Michihiko Sone Tsutomu Nakashima Keiji Tabuchi Tomofumi Hoshino Atsuyoshi Shimada Toyonori Tsuzuki Masahiko Yamamoto Gen Sobue Mayumi Jijiwa Naoya Asai Akira Hara Masahide Takahashi Masashi Kato

Neurobiology of aging 33(3) 626.e25-34 2012年3月 [査読有り]

c-Ret has been shown to be crucial for neural development and survival. We have recently shown that complete impairment of tyrosine 1062 (Y1062)-phosphorylation in c-Ret causes congenital hearing loss with neurodegeneration of spiral ganglion neur...

Regulatory mechanism of integrin beta 1 expression in collectively migrating cancer cells.

T. Kato A. Enomoto H. Haga S. Ishida M. Asai N. Asai M. Takahashi

MOLECULAR BIOLOGY OF THE CELL 23 2012年

Behavioral analysis of Girdin mutant mice

Tsuyoshi Nakai Taku Nagai Naoya Asai Atsushi Enomoto Masahide Takahashi Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 140P-140P 2012年

骨髄移植後アデノウイルスによる劇症肝炎をきたし亡くなった急性骨髄性白血病の1剖検例

北村彩榎本篤浅井直也下山芳江川島希高橋義行小島勢二中村栄男高橋雅英

日本病理学会会誌 101(1) 2012年