Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...
Genes to cells : devoted to molecular & cellular mechanisms 2023年2月 [査読有り]
Epithelial-mesenchymal transition (EMT) plays a pivotal role in cancer metastasis and treatment resistance, which worsens prognosis. In phase III trials, eribulin improved overall survival in metastatic breast cancer (MBC) patients. In preclinical...
Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute to chronic kidney disease progression. Several PMC markers have been identified; however, PMC heterogeneity and functions are not...
Ohgami N   Ida M   Shimotake T   Sakashita N   Sone M   Nakashima T   Tabuchi K   Hoshino T   Shimada A   Tsuzuki T   Yamamoto M   Sobue G   Jijiwa M   Asai N   Hara A   Takahashi M   Kato M   
Cell migration is a critical cellular process that determines embryonic development and the progression of human diseases. Therefore, cell- or context-specific mechanisms by which multiple promigratory proteins differentially regulate cell migrati...
Familial neurohypophysial diabetes insipidus (FNDI) is caused by mutations in the gene locus of arginine vasopressin (AVP), an antidiuretic hormone. Although the carriers are normal at birth, polyuria and polydipsia appear several months or years ...
The glial cell line-derived neurotrophic factor (GDNF)-RET signaling pathway plays an important role in kidney development. We have previously identified a novel zinc finger protein, glial cell line-derived neurotrophic factor-inducible zinc finge...
Yun Wang   Naoko Kaneko   Naoya Asai   Atsushi Enomoto   Mayu Isotani-Sakakibara   Takuya Kato   Masato Asai   Yoshiki Murakumo   Haruko Ota   Takao Hikita   Takashi Namba   Keisuke Kuroda   Kozo Kaibuchi   Guo-li Ming   Hongjun Song   Kazunobu Sawamoto   Masahide Takahashi   
The Journal of neuroscience : the official journal of the Society for Neuroscience 31(22) 8109-22 2011年6月 [査読有り]
In postnatally developing and adult brains, interneurons of the olfactory bulb (OB) are continuously generated at the subventricular zone of the forebrain. The newborn neuroblasts migrate tangentially to the OB through a well defined pathway, the ...