研究者氏名	浅井直也
	アサイナオヤ
所属	藤田医科大学
部署	医学部病理学講座
職名	教授
学位	博士（医学）(名古屋大学)
J-Global ID	200901070978348285

研究キーワード

遺伝子改変マウスの作製と解析

研究分野

ライフサイエンス / 実験病理学 /

経歴

2019年4月

現在

藤田医科大学医学部病理学講座教授

2009年4月

2019年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター先端応用医学部門准教授

論文

<5 678 9 >

非扁平上皮系悪性腫瘍におけるGPIアンカー型膜タンパク質CD109の発現と臨床的意義

三井伸二白木之浩滝哲郎榎本篤浅井直也高橋雅英

日本病理学会会誌 107(2) 120-120 2018年10月

Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.

Shaniya Abudureyimu Naoya Asai Atsushi Enomoto Liang Weng Hiroki Kobayashi Xiaoze Wang Chen Chen Shinji Mii Masahide Takahashi

Scientific reports 8(1) 7292-7292 2018年5月 [査読有り]

Linx is a member of the leucine-rich repeat and immunoglobulin family of membrane proteins which has critical roles in the development of the peripheral nervous system and forebrain connectivity. A previous study showed that Linx is expressed in p...

腫瘍微小環境の病理学線維芽細胞多様性と硬さの観点からがんを理解するメカノパソロジーの重要性

榎本篤水谷泰之浅井直也高橋雅英

日本病理学会会誌 107(1) 187-187 2018年4月

腫瘍幹細胞におけるCD109の機能解析(The role of CD109 in Brain tumor stem cells derived from PDGFB-induced glioma mouse model)

白木之浩三井伸二浅井直也榎本篤高橋雅英

日本病理学会会誌 107(1) 380-380 2018年4月

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Liang Weng Yi-Peng Han Atsushi Enomoto Yasuyuki Kitaura Shushi Nagamori Yoshikatsu Kanai Naoya Asai Jian An Maki Takagishi Masato Asai Shinji Mii Takashi Masuko Yoshiharu Shimomura Masahide Takahashi

PLoS biology 16(3) e2005090 2018年3月 [査読有り]

Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show ...

MISC

12 3 4 5 >

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note.

Kaori Ushida Naoya Asai Kozo Uchiyama Atsushi Enomoto Masahide Takahashi

Pathology international 68(4) 241-245 2018年4月 [査読有り]

Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...

The role of CD109 in PDGFB-induced glioma mouse model for sensitivity to Temozolomide

Shiraki Yukihiro Mii Shinji Asai Naoya Enomoto Atsushi Momota Hiroyuki Natsume Atsushi Wakabayashi Toshihiko Takahashi Masahide

CANCER SCIENCE 109 1130-1130-1130 2018年1月

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.

Yukihiro Shiraki Shinji Mii Atsushi Enomoto Hiroyuki Momota Yi-Peng Han Takuya Kato Kaori Ushida Akira Kato Naoya Asai Yoshiki Murakumo Kosuke Aoki Hiromichi Suzuki Fumiharu Ohka Toshihiko Wakabayashi Tomoki Todo Seishi Ogawa Atsushi Natsume Masahide Takahashi

The Journal of pathology 243(4) 468-480 2017年12月 [査読有り]

In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies. Some of these cells are considered to be brain tumour stem cells (BTSCs); however, the m...

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.

Maki Takagishi Masato Sawada Shinya Ohata Naoya Asai Atsushi Enomoto Kunihiko Takahashi Liang Weng Kaori Ushida Hosne Ara Shigeyuki Matsui Kozo Kaibuchi Kazunobu Sawamoto Masahide Takahashi

Cell reports 20(4) 960-972 2017年7月 [査読有り]

Motile cilia in ependymal cells, which line the cerebral ventricles, exhibit a coordinated beating motion that drives directional cerebrospinal fluid (CSF) flow and guides neuroblast migration. At the apical cortex of these multi-ciliated cells, a...

Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.

Daisuke Kuga Kaori Ushida Shinji Mii Atsushi Enomoto Naoya Asai Masato Nagino Masahide Takahashi Masato Asai

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 65(6) 347-366 2017年6月 [査読有り]

Tuft cells (TCs) are minor components of gastrointestinal epithelia, characterized by apical tufts and spool-shaped somas. The lack of reliable TC-markers has hindered the elucidation of its role. We developed site-specific and phosphorylation-sta...