研究者氏名	永野修
	ナガノオサム
URL
所属	藤田医科大学
部署	がん医療研究センター　遺伝子制御研究部門
職名	教授
学位	医学博士(熊本大学)
科研費研究者番号	30404346
ORCID ID	0000-0002-7630-142X
J-Global ID	200901013210371837

研究キーワード

腫瘍生物学

研究分野

ライフサイエンス / 病態医化学 /

経歴

2023年4月

現在

藤田医科大学がん医療研究センター遺伝子制御研究部門教授

2018年5月

2023年3月

慶應義塾大学医学部准教授

2012年4月

2018年4月

慶應義塾大学医学部講師

2007年4月

2012年3月

慶應義塾大学医学部助教

1999年6月

2001年3月

九州大学歯学部研修医

学歴

2001年4月

2005年3月

熊本大学医学部

1993年4月

1999年3月

広島大学歯学部

受賞

2011年10月

日本癌学会, 日本癌学会奨励賞,癌幹細胞マーカーCD44の機能解析

論文

RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination.

Jun Zhang Lingfeng Fu Huaitao Wang Atsuko Yonemura Takashi Semba Noriko Yasuda-Yoshihara Akiho Nishimura Takuya Tajiri Yilin Tong Tadahito Yasuda Tomoyuki Uchihara Masaya Yamazaki Yuya Okamoto Juntaro Yamasaki Osamu Nagano Hideo Baba Takatsugu Ishimoto

Cancer letters 591 216901-216901 2024年4月 [査読有り]

Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer that is prone to peritoneal dissemination, with poor patient prognosis. Although intercellular adhesion loss between cancer cells is a major characteristic of DGCs, the mechanism und...

Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment.

Atsuko Yonemura Takashi Semba Jun Zhang Yibo Fan Noriko Yasuda-Yoshihara Huaitao Wang Tomoyuki Uchihara Tadahito Yasuda Akiho Nishimura Lingfeng Fu Xichen Hu Feng Wei Fumimasa Kitamura Takahiko Akiyama Kohei Yamashita Kojiro Eto Shiro Iwagami Masaaki Iwatsuki Yuji Miyamoto Keisuke Matsusaki Juntaro Yamasaki Osamu Nagano Hideyuki Saya Shumei Song Patrick Tan Hideo Baba Jaffer A Ajani Takatsugu Ishimoto

Cell reports 43(1) 113613-113613 2024年1月 [査読有り]

Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a com...

Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer.

Fumimasa Kitamura Takashi Semba Noriko Yasuda-Yoshihara Kosuke Yamada Akiho Nishimura Juntaro Yamasaki Osamu Nagano Tadahito Yasuda Atsuko Yonemura Yilin Tong Huaitao Wang Takahiko Akiyama Kazuki Matsumura Norio Uemura Rumi Itoyama Luke Bu Lingfeng Fu Xichen Hu Feng Wei Kosuke Mima Katsunori Imai Hiromitsu Hayashi Yo-Ichi Yamashita Yuji Miyamoto Hideo Baba Takatsugu Ishimoto

JCI insight 8(20) 2023年9月 [査読有り]

Glycolysis is highly enhanced in Pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). However, little is known about how such glucose competition alters m...

Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.

Akiyama T Yasuda T Uchihara T Yasuda-Yoshihara N Tan BJY Yonemura A Semba T Yamasaki J Komohara Y Ohnishi K Wei F Fu L Zhang J Kitamura F Yamashita K Eto K Iwagami S Tsukamoto H Umemoto T Masuda M Nagano O Satou Y Saya H Tan P Baba H Ishimoto T

Cancer research 83(5) 753-770 2022年12月 [査読有り]

Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.

Yibo Fan Yuan Li Xiaodan Yao Jiangkang Jin Ailing Scott Bovey Liu Shan Wang Longfei Huo Ying Wang Ruiping Wang Melissa Pool Pizzi Lang Ma Shan Shao Matheus Sewastjanow-Silva Rebecca Waters Deyali Chatterjee Bin Liu Namita Shanbhag Guang Peng George Adrian Calin Pawel Karol Mazur Samir M Hanash Jo Ishizawa Yuki Hirata Osamu Nagano Zhenning Wang Linghua Wang Wa Xian Frank McKeon Jaffer A Ajani Shumei Song

Gut 72(4) 624-637 2022年8月 [査読有り]

OBJECTIVE: Many cancers engage embryonic genes for rapid growth and evading the immune system. SOX9 has been upregulated in many tumours, yet the role of SOX9 in mediating immunosuppressive tumour microenvironment is unclear. Here, we aim to disse...

もっとみる

MISC

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Sulfasalazine (SSZ) works cancer stem-like cells (CSCs) via inhibiting xCT signal pathway: Phase 1 study in patients with gastric cancer (EPOC 1205)

Kohei Shitara Shunji Takahashi Takako Nakajima Hironaka Shuichi Osamu Nagano Chiyo Imamura Taisei Mushiroda Yasuaki Einaga Miki Fukunani Akihiro Sato Atsushi Ohtsu Hideyuki Saya Toshihiko Doi

CANCER RESEARCH 74(19) 2014年10月

ESRP1 regulated alternative splicing of CD44mRNA enhances lung colonization of metastatic cancer cell

Kenji Tsuchihashi Osamu Nagano Toshifumi Yae Takatsugu Ishimoto Takeshi Motohara Momoko Yoshikawa Go J. Yoshida Takeyuki Wada Takashi Masuko Kaoru Mogushi Hiroshi Tanaka Tsuyoshi Osawa Yasuharu Kanki Takashi Minami Hiroyuki Aburatani Mitsuyo Ohmura Akiko Kubo Makoto Suematsu Kazuhisa Takahashi Eishi Baba Koichi Akashi Hideyuki Saya

CANCER RESEARCH 74(19) 2014年10月

Effect of sulfasalazine (SSZ) on cancer stem-like cells (CSCs) via inhibiting xCT signal pathway: Phase 1 study in patients with gastric cancer (EPOC 1205).

Kohei Shitara Shunji Takahashi Takako Eguchi Nakajima Shuichi Hironaka Osamu Nagano Chiyo K. Imamura Miki Fukunani Hiromi Hasegawa Akihiro Sato Atsushi Ohtsut Atsushi Ohtsu Hideyuki Saya Toshihiko Doi

JOURNAL OF CLINICAL ONCOLOGY 32(15) 2014年5月

Ink4a/Arf遺伝子座は壁細胞脱落を誘導することで胃発癌を促進する

清島亮永野修吉川桃子土橋賢治岡崎章吾北川雄光佐谷秀行

日本消化器癌発生学会総会プログラム・抄録集 25th 99 2014年

xCT阻害はCD44v陽性口腔扁平上皮癌細胞の生体内における増殖を抑制する

吉川桃子永野修莇生田整治河奈裕正中川種昭佐谷秀行

日本口腔科学会雑誌 63(1) 136-137 2014年1月