Midkine (MK), a heparin-binding growth factor, has been shown to prevent cardiac remodeling after ischemic injury through its anti-apoptotic effect. Cell apoptosis is central to the pathophysiology of cardiac remodeling in congestive heart failure...
BACKGROUND Cardiac sarcoidosis (CS) generates myocardial scar and arrhythmogenic substrate. CS diagnosis according to the Japanese Ministry of Health and Welfare guidelines relies, among others, on cardiac magnetic resonance imaging with late gado...
Background
Atrial fibrillation (AF) is a significant risk factor for ischemic strokes, and making a robust risk stratification scheme would be important. Few studies have examined whether nonlinear dynamics of the heart rate could predict ischemic...
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 66(1) 47-58 2015年7月 [査読有り]
BACKGROUND Atrial fibrillation (AF) is associated with metabolic stress, which activates adenosine monophosphate-regulated protein kinase (AMPK).
OBJECTIVES This study sought to examine AMPK response to AF and associated metabolic stress, along wi...
CIRCULATION RESEARCH 116(5) 836-845 2015年2月 [査読有り]
Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional impo...
Harada M   Nomura Y   Nishimura A   Motoike Y   Koshikawa M   Watanabe E   Izawa H   Ozaki Y