Yukie Yamahashi You-Hsin Lin Akihiro Mouri Sho Iwanaga Kazuhiro Kawashima Yuya Tokumoto Yo Watanabe Md Omar Faruk Xinjian Zhang Daisuke Tsuboi Takashi Nakano Naoaki Saito Taku Nagai Kiyofumi Yamada Kozo Kaibuchi

Molecular psychiatry 27(8) 3479-3492 2022年6月

Acetylcholine is a neuromodulator critical for learning and memory. The cholinesterase inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer's disease (AD)-associated learning disabilities. Acetylcholine activates striata...

Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology

Mengya Wu Yasuhiro Funahashi Tetsuya Takano Emran Hossen Rijwan Uddin Ahammad Daisuke Tsuboi Mutsuki Amano Kiyofumi Yamada Kozo Kaibuchi

Neurochemical Research 2022年5月

Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning.

Md Omar Faruk Daisuke Tsuboi Yukie Yamahashi Yasuhiro Funahashi You-Hsin Lin Rijwan Uddin Ahammad Emran Hossen Mutsuki Amano Tomoki Nishioka Anastasios V Tzingounis Kiyofumi Yamada Taku Nagai Kozo Kaibuchi

Journal of neurochemistry 160(3) 325-341 2022年2月

The nucleus accumbens (NAc) plays critical roles in emotional behaviors, including aversive learning. Aversive stimuli such as an electric foot shock increase acetylcholine (ACh) in the NAc, and muscarinic signaling appears to increase neuronal ex...

NMDAによるCaMKII-RhoA-Rho-kinase経路の活性化が忌避学習を制御する

船橋靖広 Ahammad Rijwan Uddin 張心健 Emran Hossen Faruk Md. Omar 王緩緩呉敏華許伊凡坪井大輔西岡朋生黒田啓介天野睦紀崎村建司内野茂夫山田清文永井拓貝淵弘三

日本薬理学会年会要旨集 96 2-B-P-109 2022年

Glutamate induces Ca²⁺ influx in neurons through NMDA receptors (NMDARs) and activates Ca²⁺-dependent protein kinases, including CaMKII, which play critical roles in synaptic plasticity and learning. However, how these kinase...

KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain

Rijwan Uddin Ahammad Tomoki Nishioka Junichiro Yoshimoto Takayuki Kannon Mutsuki Amano Yasuhiro Funahashi Daisuke Tsuboi Md. Omar Faruk Yukie Yamahashi Kiyofumi Yamada Taku Nagai Kozo Kaibuchi

Cells 11(1) 47-47 2021年12月

Protein phosphorylation plays critical roles in a variety of intracellular signaling pathways and physiological functions that are controlled by neurotransmitters and neuromodulators in the brain. Dysregulation of these signaling pathways has been...

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Mechanism of dopamine signaling for membrane excitability

D. Tsuboi T. Shimomura T. Nakano T. Nagai M. Amano J. Yoshimoto Y. Kubo K. Kaibuchi

JOURNAL OF NEUROCHEMISTRY 142 135-135 2017年8月

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

Taku Nagai Shinichi Nakamuta Keisuke Kuroda Sakura Nakauchi Tomoki Nishioka Tetsuya Takano Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Takashi Nakano Junichiro Yoshimoto Kenta Kobayashi Motokazu Uchigashima Masahiko Watanabe Masami Miura Akinori Nishi Kazuto Kobayashi Kiyofumi Yamada Mutsuki Amano Kozo Kaibuchi

Neuron 89(3) 550-65 2016年2月 [査読有り]

Dopamine (DA) type 1 receptor (D1R) signaling in the striatum presumably regulates neuronal excitability and reward-related behaviors through PKA. However, whether and how D1Rs and PKA regulate neuronal excitability and behavior remain largely unk...

注目の遺伝子(第31回)統合失調症発症脆弱性分子DISC1の研究から明らかになった課題と新機能

坪井大輔森大輔黒田啓介

分子精神医学 15(4) 301-303 2015年10月

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi Taku Nagai Akira Nakajima Hiroyuki Mizoguchi Takahiro Kawase Daisuke Tsuboi Shin-Ichi Kano Yoshiaki Sato Masahiro Hayakawa Ulrike C. Lange David J. Adams M. Azim Surani Takaya Satoh Akira Sawa Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada

GLIA 61(5) 679-693 2013年5月

Interferon-induced transmembrane protein 3 (IFITM3) plays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expres...

精神疾患を分子生物学で考えてみる : 統合失調症発症脆弱性因子DISC1をモデルとして

貝淵弘三坪井大輔

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 30(3) 149-152 2010年6月