In Caenorhabditis elegans, unc-33 encodes an orthologue of the vertebrate collapsin response mediator protein (CRMP) family. We previously reported that CRMP-2 accumulated in the distal part of the growing axon of vertebrate neurons and played cri...

CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.

Kawano Y Yoshimura T Tsuboi D Kawabata S Kaneko-Kawano T Shirataki H Takenawa T Kaibuchi K

Molecular and Cellular Biology 25(22) 9920-9935 2005年11月 [査読有り]

Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.

Hikita T Qadota H Tsuboi D Taya S Moerman DG Kaibuchi K

Biochemical and biophysical research communications 335(1) 139-145 2005年9月 [査読有り]

The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C-elegans

MC Soto H Qadota K Kasuya M Inoue D Tsuboi CC Mello K Kaibuchi

GENES & DEVELOPMENT 16(5) 620-632 2002年3月 [査読有り]

During body morphogenesis precisely coordinated cell movements and cell shape changes organize the newly differentiated cells of an embryo into functional tissues. Here we describe two genes, gex-2 and gex-3, whose activities are necessary for ini...

MISC

12 >

Mechanism of dopamine signaling for membrane excitability

D. Tsuboi T. Shimomura T. Nakano T. Nagai M. Amano J. Yoshimoto Y. Kubo K. Kaibuchi

JOURNAL OF NEUROCHEMISTRY 142 135-135 2017年8月

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

Taku Nagai Shinichi Nakamuta Keisuke Kuroda Sakura Nakauchi Tomoki Nishioka Tetsuya Takano Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Takashi Nakano Junichiro Yoshimoto Kenta Kobayashi Motokazu Uchigashima Masahiko Watanabe Masami Miura Akinori Nishi Kazuto Kobayashi Kiyofumi Yamada Mutsuki Amano Kozo Kaibuchi

Neuron 89(3) 550-65 2016年2月 [査読有り]

Dopamine (DA) type 1 receptor (D1R) signaling in the striatum presumably regulates neuronal excitability and reward-related behaviors through PKA. However, whether and how D1Rs and PKA regulate neuronal excitability and behavior remain largely unk...

注目の遺伝子(第31回)統合失調症発症脆弱性分子DISC1の研究から明らかになった課題と新機能

坪井大輔森大輔黒田啓介

分子精神医学 15(4) 301-303 2015年10月

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi Taku Nagai Akira Nakajima Hiroyuki Mizoguchi Takahiro Kawase Daisuke Tsuboi Shin-Ichi Kano Yoshiaki Sato Masahiro Hayakawa Ulrike C. Lange David J. Adams M. Azim Surani Takaya Satoh Akira Sawa Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada

GLIA 61(5) 679-693 2013年5月

Interferon-induced transmembrane protein 3 (IFITM3) plays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expres...

精神疾患を分子生物学で考えてみる : 統合失調症発症脆弱性因子DISC1をモデルとして

貝淵弘三坪井大輔

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 30(3) 149-152 2010年6月