日本神経精神薬理学会, JSNP Excellent Presentation Award for AsCNP,The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
British journal of pharmacology 177(14) 3210-3224 2020年7月 [査読有り]
BACKGROUND AND PURPOSE: Hispidulin is a flavonoid isolated from Clerodendrum inerme that was found to inhibit intractable motor tics. Previously, we found that hispidulin attenuates hyperlocomotion and the disrupted prepulse inhibition induced by ...
Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this study was to investigate the characteristics of the serum TRP-KYN pathway ...
Qiaohui Lu   Akihiro Mouri   Yang Yang   Kazuo Kunisawa   Tomoaki Teshigawara   Mami Hirakawa   Yuko Mori   Yasuko Yamamoto   Zou Libo   Toshitaka Nabeshima   Kuniaki Saito   
Behavioural brain research 372 112053-112053 2019年10月 [査読有り]
Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways aff...
Tryptophan metabolism is important to induce immune tolerance in tumors. To date, 3 types of tryptophan-metabolizing enzymes have been identified: indoleamine 2,3-dioxygenase 1 and 2 (IDO1 and IDO2) and tryptophan 2,3-dioxygenase 2. Numerous studi...
Journal of affective disorders 255 168-176 2019年8月 [査読有り]
BACKGROUND: Many women experience depressive symptoms during pregnancy and postpartum periods. These depressive symptoms are often accompanied by other inflammatory morbidities present during pregnancy. Tryptophan (TRP) metabolism has attracted co...