Yoko S. Kaneko   Akira Ota   Akira Nakashima   Keiji Mori   Ikuko Nagatsu   Toshiharu Nagatsu   
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 39(7) 599-607 2012年7月 [査読有り]
Previously, we reported that an optimal dose of lipopolysaccharide (LPS) markedly extends the life span of mouse primary-cultured microglia by suppressing apoptotic and autophagic cell death pathways. The aim of the present study was to assess how...
Background: Activated microglia secrete inflammatory cytokines and may play roles in the progression of neurodegenerative diseases. However, the mechanism underlying microglial activation remains unclear. Objective: Our aim was to examine the regu...
Akira Nakashima   Keiji Mori   Yoko S. Kaneko   Nobuhiro Hayashi   Toshiharu Nagatsu   Akira Ota   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407(2) 343-347 2011年4月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. In the present study, we investigated the mechanism by which the N-terminal...