Yoko S. Kaneko Akira Nakashima Keiji Mori Toshiharu Nagatsu Ikuko Nagatsu Akira Ota
BRAIN RESEARCH 1279 9-20 2009年7月 [査読有り]
Microglial activation has been implicated in the recognition and phagocytic removal of degenerating neurons; however, this process must be tightly regulated in the central nervous system, because prolonged activation could damage normal neurons. W...
Akira Ota Keiji Mori Yoko S. Kaneko Akira Nakashima Ikuko Nagatsu Toshiharu Nagatsu
Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms 1148 127-135 2008年 [査読有り]
Peripheral administration of lipopolysaccharide (LPS) in an amount that produces acute stress has been found to affect the catecholamine systems in the brain. Acute peripheral LPS administration activated norepinephrine (NE) metabolism in the locu...
Akira Nakashima Nobuhiro Hayashi Yoko S. Kaneko Keiji Mori Esther L. Sabban Toshiharu Nagatsu Akira Ota
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363(3) 817-821 2007年11月 [査読有り]
Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. In the present study, we investigated the mechanism by which the N-terminus of h...
Joseph R. Mazzulli Amanda J. Mishizen Benoit I. Giasson David R. Lynch Steven A. Thomas Akira Nakashima Toshiharu Nagatsu Akira Ota Harry Ischiropoulos
JOURNAL OF NEUROSCIENCE 26(39) 10068-10078 2006年9月 [査読有り]
Aberrant aggregation of alpha-synuclein (alpha-syn) to form fibrils and insoluble aggregates has been implicated in the pathogenic processes of many neurodegenerative diseases. Despite the dramatic effects of dopamine in inhibiting the formation o...
お知らせ・マニュアル
医学部