Bi H   Tranell J   Harper DC   Lin W   Li J   Hellström AR   Larsson M   Rubin CJ   Wang C   Sayyab S   Kerje S   Bed'hom B   Gourichon D   Ito S   Wakamatsu K   Andersson L   
PLoS genetics 19(4) e1010724 2023年4月
The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) is a plumage colour variant in chicken that provides an opportunity...
Yasuaki Tamura   Akira Ito   Kazumasa Wakamatsu   Toshihiko Torigoe   Hiroyuki Honda   Shosuke Ito   Kowichi Jimbow   
International Journal of Molecular Sciences 24(6) 2023年3月
N-propionyl-4-S-cysteaminylphenol (N-Pr-4-S-CAP) is a substrate for tyrosinase, which is a melanin biosynthesis enzyme and has been shown to be selectively incorporated into melanoma cells. It was found to cause selective cytotoxicity against mela...
Nagatsu T   Nakashima A   Watanabe H   Ito S   Wakamatsu K   Zucca FA   Zecca L   Youdim M   Wulf M   Riederer P   Dijkstra JM   
Journal of neural transmission (Vienna, Austria : 1996) 130(5) 611-625 2023年3月
Abstract
The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in the human brain. During the progression of Parkinson’s dis...
Ana-Maria Pena   Shosuke Ito   Thomas Bornschlögl   Sébastien Brizion   Kazumasa Wakamatsu   Sandra Del Bino   
International Journal of Molecular Sciences 24(5) 2023年2月
To better understand the impact of solar light exposure on human skin, the chemical characterization of native melanins and their structural photo-modifications is of central interest. As the methods used today are invasive, we investigated the po...
Okamura, K   Araki, Y   Abe, Y   Wakamatsu, K   Tamiya, G   Seishima, M   Umetsu, T   Kato, A   Kawaguchi, M   Hayashi, M   Hozomi, Y   Suzuki, T   
23rd International Pigment Cell Conference. 2017年8月27日