Waijiao Cai   Kazumasa Wakamatsu   Fabio A Zucca   Qing Wang   Kai Yang   Niyaz Mohamadzadehonarvar   Pranay Srivastava   Hitomi Tanaka   Gabriel Holly   Luigi Casella   Shosuke Ito   Luigi Zecca   Xiqun Chen   
Progress in neurobiology 223 102414-102414 2023年2月
Neuromelanin (NM) in dopaminergic neurons of human substantia nigra (SN) has a melanic component that consists of pheomelanin and eumelanin moieties and has been proposed as a key factor contributing to dopaminergic neuron vulnerability in Parkins...
Shosuke Ito   Alessandra Napolitano   Tadeusz Sarna   Kazumasa Wakamatsu   
Journal of neural transmission (Vienna, Austria : 1996) 130(1) 29-42 2023年1月
Dopamine (DA) is a precursor of neuromelanin (NM) synthesized in the substantia nigra of the brain. NM is known to contain considerable levels of Fe and Cu. However, how Fe and Cu ions affect DA oxidation to DA-eumelanin (DA-EM) and modify its str...
Takashi Itou   Shosuke Ito   Kazumasa Wakamatsu   
International journal of molecular sciences 23(22) 2022年11月
In a previous study, we observed that the hair color of Japanese females darkens with age and that the causes of this are the increase in melanosome size, the amount of melanin, and the mol% of 5,6-dihydroxyindole (DHI) which has a high absorbance...
Kazumasa Wakamatsu   Akira Ito   Yasuaki Tamura   Tokimasa Hida   Takafumi Kamiya   Toshihiko Torigoe   Hiroyuki Honda   Shosuke Ito   Kowichi Jimbow   
Cancers 14(22) 2022年11月
Malignant melanoma is one of the most malignant of all cancers. Melanoma occurs at the epidermo-dermal interface of the skin and mucosa, where small vessels and lymphatics are abundant. Consequently, from the onset of the disease, melanoma easily ...
Tomoko Nishimaki-Mogami   Shosuke Ito   Hongyan Cui   Takumi Akiyama   Norimasa Tamehiro   Reiko Adachi   Kazumasa Wakamatsu   Yoshiaki Ikarashi   Kazunari Kondo   
Journal of dermatological science 108(2) 77-86 2022年11月
BACKGROUND: Chemical leukoderma is a skin depigmentation disorder induced through contact with certain chemicals, most of which have a p-substituted phenol structure similar to the melanin precursor tyrosine. The tyrosinase-catalyzed oxidation of ...
Okamura, K   Araki, Y   Abe, Y   Wakamatsu, K   Tamiya, G   Seishima, M   Umetsu, T   Kato, A   Kawaguchi, M   Hayashi, M   Hozomi, Y   Suzuki, T   
23rd International Pigment Cell Conference. 2017年8月27日