Chelsey D Kline Madeleine Anderson John W Bassett Gail Kent Rachel Berryman Matthew Honeggar Shosuke Ito Kazumasa Wakamatsu Arup K Indra Philip J Moos Sancy A Leachman Pamela B Cassidy
Cancers 14(20) 2022年10月
TR1 and other selenoproteins have paradoxical effects in melanocytes and melanomas. Increasing selenoprotein activity with supplemental selenium in a mouse model of UV-induced melanoma prevents oxidative damage to melanocytes and delays melanoma t...
Yoko Niki Naoko Adachi Masaki Fukata Yuko Fukata Shinichiro Oku Chieko Makino-Okamura Seiji Takeuchi Kazumasa Wakamatsu Shosuke Ito Lieve Declercq Daniel B. Yarosh Tomas Mammone Chikako Nishigori Naoaki Saito Takehiko Ueyama
Journal of Investigative Dermatology 143(2) 317-327 2022年9月
Palmitoylation is a lipid modification involving the attachment of palmitic acid to a cysteine residue, thereby affecting protein function. We investigated the effect of palmitoylation of tyrosinase, the rate-limiting enzyme in melanin synthesis, ...
Emily E. Puckett Isis S. Davis Dawn C. Harper Kazumasa Wakamatsu Gopal Battu Jerrold L. Belant Dean E. Beyer, Jr. Colin Carpenter Anthony P. Crupi Maria Davidson Christopher S. DePerno Nicholas Forman Nicholas L. Fowler David L. Garshelis Nicholas Gould Kerry Gunther Mark Haroldson Shosuke Ito David Kocka Carl Lackey Ryan Leahy Caitlin Lee-Roney Tania Lewis Ashley Lutto Kelly McGowan Colleen Olfenbuttel Mike Orlando Alexander Platt Matthew D. Pollard Megan Ramaker Heather Reich Jaime L. Sajecki Stephanie K. Sell Jennifer Strules Seth Thompson Frank van Manen Craig Whitman Ryan Williamson Frederic Winslow Christopher B. Kaelin Michael S. Marks Gregory S. Barsh
Current Biology 33(1) 86-97 2022年8月
Color variation is a frequent evolutionary substrate for camouflage in small mammals, but the underlying genetics and evolutionary forces that drive color variation in natural populations of large mammals are mostly unexplained. The American black...
Sandra Del Bino Shosuke Ito Juliette Sok Kazumasa Wakamatsu
Pigment Cell & Melanoma Research 35(6) 622-626 2022年8月
Human skin contains two distinct components: brown to black, insoluble eumelanin and light colored, alkaline-soluble pheomelanin. Eumelanin consists of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) moieties, while phe...
Yasuaki Tamura Akira Ito Kazumasa Wakamatsu Takafumi Kamiya Toshihiko Torigoe Hiroyuki Honda Toshiharu Yamashita Hisashi Uhara Shosuke Ito Kowichi Jimbow
International Journal of Molecular Sciences 23(12) 2022年6月
A major advance in drug discovery and targeted therapy directed at cancer cells may be achieved by the exploitation and immunomodulation of their unique biological properties. This review summarizes our efforts to develop novel chemo-thermo-immuno...
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