JOURNAL OF NEURAL TRANSMISSION 124(6) 739-744 2017年6月 [査読有り]
Prolyl oligopeptidase (also named prolyl endopeptidase; PREP) hydrolyzes the Pro-Xaa bonds of biologically active oligopeptides on their carboxyl side. In 1987, we detected PREP activity in human cerebrospinal fluid (CSF) using highly sensitive li...
Akira Nakashima   Syuhei Ohnuma   Yu Kodani   Yoko S. Kaneko   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 472(4) 598-602 2016年4月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. However, the intracellular stability determined by the degradation...
Kaneko YS   Takayanagi T   Nagasaki H   Kodani Y   Nakashima A   Mori K   Suzuki A   Itoh M   Kondo K   Nagatsu T   Ota M   Ota A   
Journal of neural transmission (Vienna, Austria : 1996) 122(6) 757-772 2015年6月 [査読有り]
JOURNAL OF NEURAL TRANSMISSION 123(11) 1255-1278 2016年11月
Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs),...
Y. S. Kaneko   A. Nakashima   K. Mori   H. Nagasaki   Y. Kodani   I. Nagatsu   T. Nagatsu   A. Ota