Primer on the Autonomic Nervous System 45-47 2012年 [査読有り]
This chapter explains how tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine to 3,4- dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthetic pathway of catecholamines including dopamine, norad...
Ikemoto K   Suzuki T   Ichinose H   Ohye T   Nishimura A   Nishi K   Nagatsu I   Nagatsu T   
Objectives- We examined the relationship between severity of depression in Parkinson's disease (PD) and regional cerebral blood flow (rCBF) using single photon emission computed tomography (SPECT) and the reaction to levodopa-selegiline combinatio...
JOURNAL OF NEURAL TRANSMISSION 123(11) 1255-1278 2016年11月
Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs),...
Y. S. Kaneko   A. Nakashima   K. Mori   H. Nagasaki   Y. Kodani   I. Nagatsu   T. Nagatsu   A. Ota