Cripto-1, a co-receptor for Nodal, can activate Nodal-dependent and Nodal-independent signaling pathways. In this study we have investigated whether Cripto-1 mutants, that fail to activate a Nodal-dependent signaling pathway, are capable to activa...
Luigi Strizzi   Mario Mancino   Caterina Bianco   Ahmed Raafat   Monica Gonzales   Brian W. Booth   Kazuhide Watanabe   Tadahiro Nagaoka   David L. Mack   Beatrice Howard   Robert Callahan   Gilbert H. Smith   David S. Salomon   
JOURNAL OF CELLULAR PHYSIOLOGY 216(3) 824-834 2008年9月 [査読有り]
Netrin-1 has been shown to regulate the function of the EGF-like protein Cripto-1 (Cr-1) and affect mammary gland development. Since Cr-1 is a target gene of Nanog and Oct4, we investigated the relationship between Netrin-1 and Cr-1, Nanog and Oct...
Both canonical Wnt/beta-catenin and TGF beta/Smad signaling pathways coordinately regulate pattern formation during embryogenesis as well as tumor progression. Evidence of cross-talk between these two pathways has been reported. Here we demonstrat...
Yoritsuna Yamamoto   Satoko Yamada   Tsutomu Kodera   Akemi Hara   Kazuo Motoyoshi   Yuji Tanaka   Tadahiro Nagaoka   Masaharu Seno   Itaru Kojima   
GROWTH FACTORS 26(4) 173-179 2008年8月 [査読有り]
Previous studies have shown the efficacy of betacellulin (BTC) to promote P-cell regeneration. Because of its short half-life, however, the effect of BTC may have been underestimated. This study was conducted to assess the effect of continuous adm...
Toshihiro Hashizume   Takayuki Fukuda   Tadahiro Nagaoka   Hiroko Tada   Hidenori Yamada   Kazuhide Watanabe   David S. Salomon   Masaharu Seno   
CELL BIOLOGY INTERNATIONAL 32(7) 814-826 2008年7月 [査読有り]
ErbB2, which is a member of the epidermal growth factor (erbB) receptor family, is frequently overexpressed in breast and ovarian cancers. Antibody and small molecule anti-tyrosine kinase inhibitors have been developed for targeted therapies for c...