DNA damage induces hyper-phosphorylation of the Sp1 transcriptional factor. We have demonstrated that ionizing radiation-associated DNA double-strand breaks (DSBs) induce phosphorylation of at least Ser-56 and Ser-101 residues on Sp1 in an ATM-dep...
Hiroki Isomura Mark F Stinski Ayumi Kudoh Takayuki Murata Sanae Nakayama Yoshitaka Sato Satoko Iwahori Tatsuya Tsurumi
Journal of virology 82(4) 1638-46 2008年2月 [査読有り]
During productive infection, human cytomegalovirus (HCMV) UL44 transcription initiates at three distinct start sites that are differentially regulated. Two of the start sites, the distal and the proximal, are active at early times, whereas the mid...
Hiroki Isomura Mark F Stinski Ayumi Kudoh Sanae Nakayama Takayuki Murata Yoshitaka Sato Satoko Iwahori Tatsuya Tsurumi
Journal of virology 82(2) 849-58 2008年1月 [査読有り]
The promoter of the major immediate-early (MIE) genes of human cytomegalovirus (HCMV), also referred to as the CMV promoter, possesses a cis-acting element positioned downstream of the TATA box between positions -14 and -1 relative to the transcri...
Satoko Iwahori Noriko Shirata Yasushi Kawaguchi Sandra K Weller Yoshitaka Sato Ayumi Kudoh Sanae Nakayama Hiroki Isomura Tatsuya Tsurumi
Journal of virology 81(18) 9653-64 2007年9月 [査読有り]
The ataxia telangiectasia-mutated (ATM) protein, a member of the related phosphatidylinositol 3-like kinase family encoded by a gene responsible for the human genetic disorder ataxia telangiectasia, regulates cellular responses to DNA damage and v...
Hiroki Isomura Mark F Stinski Ayumi Kudoh Sanae Nakayama Satoko Iwahori Yoshitaka Sato Tatsuya Tsurumi
Journal of virology 81(12) 6197-206 2007年6月 [査読有り]
Transcription of the DNA polymerase processivity factor gene (UL44) of human cytomegalovirus initiates at three distinct start sites, which are differentially regulated during productive infection. Two of these start sites, the distal and proximal...
The Journal of general virology 85(Pt 10) 2857-2862 2004年10月 [査読有り]
The accumulation of cellular proliferating cell nuclear antigen (PCNA) in the nucleus of Sf9 cells has been shown to increase upon infection with Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV). Here, analysis by DNase I treatment...
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