研究者氏名	吉田悟
	ヨシダサトル
所属	藤田医科大学
部署	国際再生医療センター
職名
学位	博士（理学）(総合研究大学院大学)

研究分野

ライフサイエンス / 分子生物学 /
ライフサイエンス / 細胞生物学 / 幹細胞再生医療

論文

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The Semaphorin 3A Inhibitor SM-345431 Accelerates Peripheral Nerve Regeneration and Sensitivity in a Murine Corneal Transplantation Model

Masahiro Omoto Satoru Yoshida Hideyuki Miyashita Tetsuya Kawakita Kenji Yoshida Akiyoshi Kishino Toru Kimura Shinsuke Shibata Kazuo Tsubota Hideyuki Okano Shigeto Shimmura

PLOS ONE 7(11) e47716 2012年11月 [査読有り]

Background: Peripheral nerve damage of the cornea is a complication following surgery or infection which may lead to decreased visual function. We examined the efficacy of the semaphorin 3A inhibitor, SM-345431, in promoting regeneration of periph...

Generation of Stratified Squamous Epithelial Progenitor Cells from Mouse Induced Pluripotent Stem Cells

Satoru Yoshida Miyuki Yasuda Hideyuki Miyashita Yoko Ogawa Tetsu Yoshida Yumi Matsuzaki Kazuo Tsubota Hideyuki Okano Shigeto Shimmura

PLOS ONE 6(12) e28856 2011年12月 [査読有り]

Background: Application of induced pluripotent stem (iPS) cells in regenerative medicine will bypass ethical issues associated with use of embryonic stem cells. In addition, patient-specific IPS cells can be useful to elucidate the pathophysiology...

Clusterin Promotes Corneal Epithelial Cell Growth through Upregulation of Hepatocyte Growth Factor by Mesenchymal Cells In Vitro

Naoko Okada Tetsuya Kawakita Kenji Mishima Ichiro Saito Hideyuki Miyashita Satoru Yoshida Shigeto Shimmura Kazuo Tsubota

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52(6) 2905-2910 2011年5月 [査読有り]

PURPOSE. Although the cornea expresses high levels of clusterin (CLU), the role of CLU in the cornea is poorly understood. This study was performed to investigate the possible role of CLU in corneal epithelial homeostasis.
METHODS. CLU was overexp...

Retinal phototoxicity in a novel murine model of intraocular lens implantation

Toshihide Kurihara Masahiro Omoto Kousuke Noda Mari Ebinuma Shunsuke Kubota Haruna Koizumi Satoru Yoshida Yoko Ozawa Shigeto Shimmura Susumu Ishida Kazuo Tsubota

MOLECULAR VISION 15(290) 2751-2761 2009年12月 [査読有り]

Purpose: To establish a novel murine intraocular lens (IOL) implantation model to study the protective effects of colored-IOLs against retinal phototoxicity.
Methods: Two-millimeter diameter IOL buttons were created from IOLs for clinical use. Ext...

Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease

Yoko Ogawa Shigeto Shimmura Tetsuya Kawakita Satoru Yoshida Yutaka Kawakami Kazuo Tsubota

AMERICAN JOURNAL OF PATHOLOGY 175(6) 2372-2381 2009年12月 [査読有り]

Chronic graft-versus-host disease (cGVHD) of the ocular surface and lacrimal gland is a vision-threatening condition that occurs after allogencic bone marrow transplantation. in this study, we used imunohistochemistry and electron microscopy to in...