Circulation. Genomic and precision medicine 15(4) 101161CIRCGEN121003612 2022年6月 [査読有り]
BACKGROUND: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wid...
Cancer epidemiology 78 102162-102162 2022年6月 [査読有り]
BACKGROUND: Smoking is well known to be a major risk factor for cancer, and to decrease the levels of aryl hydrocarbon receptor repressor (AHRR) DNA methylation. AHRR is a key regulator for AHR signaling, which is involved in chemical metabolism a...
AIMS: This study aimed to analyze differences in sensitivity to hepatic lipid metabolism at different ages, through DNA methylation, using an experimental rat model of high-fructose corn syrup (HFCS) intake. MAIN METHODS: The experimental was divi...
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 27(5) 1-7 2022年5月 [査読有り]
BACKGROUND: Previous cross-sectional studies have shown that several circulating microRNA levels are associated with hypertension, but there are no prospective studies among general populations. OBJECTIVE: We evaluated the impact of circulating in...
The Journal of nutritional biochemistry 103 108951-108951 2022年5月 [査読有り]
There are concerns about the negative effects of fructose intake during pregnancy on the next generation. We have previously reported that offspring from dams fed with fructose during gestation and lactation demonstrate abnormal lipid metabolism i...