Rei Yoshimoto Fumiko Ishida Miyuki Yamaguchi Shigeyuki Tanaka
Frontiers in Fungal Biology 3 2022年8月 [査読有り]
The biogenesis of small non-coding RNAs is a molecular event that contributes to cellular functions. The basidiomycete fungus Ustilago maydis is a biotrophic pathogen parasitizing maize. A hallmark of its genome structure is an absence of RNAi mac...
Daisuke Kaida Takayuki Satoh Ken Ishida Rei Yoshimoto
bioRxiv 2022年1月
<title>Abstract</title>Pre-mRNA splicing is indispensable for eukaryotic gene expression. Splicing inhibition causes cell cycle arrest and cell death, which are the reasons for the potent antitumor activity of splicing inhibitors. Here, we found t...
Human pre-mRNA introns vary in size from under fifty to over a million nucleotides. We searched for essential factors involved in the splicing of human short introns by screening siRNAs against 154 human nuclear proteins. The splicing activity was...
Rei Yoshimoto Jagat K Chhipi-Shrestha Tilman Schneider-Poetsch Masaaki Furuno A Maxwell Burroughs Shohei Noma Harukazu Suzuki Yoshihide Hayashizaki Akila Mayeda Shinichi Nakagawa Daisuke Kaida Shintaro Iwasaki Minoru Yoshida
Cell chemical biology 28(9) 1356-1365 2021年3月 [査読有り]
RNA splicing, a highly conserved process in eukaryotic gene expression, is seen as a promising target for anticancer agents. Splicing is associated with other RNA processing steps, such as transcription and nuclear export; however, our understandi...
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
Specialized enzymes add methyl groups to the nitrogens of the amino acid histidine, altering the chemical properties of its imidazole ring and, in turn, the function of the modified (poly)peptide. In this issue of Genes & Development, Shimazu and ...
お知らせ・マニュアル
研究推進本部