Rei Yoshimoto Karim Rahimi Thomas B Hansen Jørgen Kjems Akila Mayeda
iScience 23(7) 101345-101345 2020年7月 [査読有り]
Circular RNAs (circRNAs) are stable non-coding RNAs with a closed circular structure. One of the best studied circRNAs is ciRS-7 (CDR1as), which acts as a regulator of the microRNA miR-7; however, its biosynthetic pathway has remained an enigma. H...
Tomonori Ueno Yuki Taga Rei Yoshimoto Akila Mayeda Shunji Hattori Kiyoko Ogawa-Goto
Proceedings of the National Academy of Sciences 116(19) 9340-9349 2019年5月 [査読有り]
One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorl...
Rei Yoshimoto Daisuke Kaida Masaaki Furuno A. Maxwell Burroughs Shohei Noma Harukazu Suzuki Yumi Kawamura Yoshihide Hayashizaki Akila Mayeda Minoru Yoshida
RNA 23(1) 47-57 2017年1月 [査読有り]
Spliceostatin A (SSA) is a methyl ketal derivative of FR901464, a potent antitumor compound isolated from a culture broth of Pseudomonas sp. no. 2663. These compounds selectively bind to the essential spliceosome component SF3b, a subcomplex of th...
Rei Yoshimoto Akila Mayeda Minoru Yoshida Shinichi Nakagawa
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1859(1) 192-199 2016年1月 [査読有り][招待有り]
A recent massive parallel sequencing analysis has shown the fact that more than 80% of the human genome is transcribed into RNA. Among many kinds of the non-protein coding RNAs, we focus on the metastasis associated lung adenocarcinoma transcript ...
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
Specialized enzymes add methyl groups to the nitrogens of the amino acid histidine, altering the chemical properties of its imidazole ring and, in turn, the function of the modified (poly)peptide. In this issue of Genes & Development, Shimazu and ...
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