Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and ...
JOURNAL OF NEUROSCIENCE 34(14) 4786-4800 2014年4月 [査読有り]
In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic lip (RL), and are required for producing GABAergic and glutamatergic neurons, respective...
Yusuke Seto Tomoya Nakatani Norihisa Masuyama Shinichiro Taya Minoru Kumai Yasuko Minaki Akiko Hamaguchi Yukiko U. Inoue Takayoshi Inoue Satoshi Miyashita Tomoyuki Fujiyama Mayumi Yamada Heather Chapman Kenneth Campbell Mark A. Magnuson Christopher V. Wright Yoshiya Kawaguchi Kazuhiro Ikenaka Hirohide Takebayashi Shin'ichi Ishiwata Yuichi Ono Mikio Hoshino
NATURE COMMUNICATIONS 5 3337 2014年2月 [査読有り]
In the cerebellum, all GABAergic neurons are generated from the Ptf1a-expressing ventricular zone (Ptf1a domain). However, the machinery to produce different types of GABAergic neurons remains elusive. Here we show temporal regulation of distinct ...
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