研究者氏名	佐野裕美
	サノヒロミ
URL
所属	藤田医科大学
部署	精神・神経病態解明センター
職名	准教授
J-Global ID	200901066461385086

研究キーワード

包括脳ネットワーク ,運動 ,大脳基底核 ,basal-ganglia

研究分野

ライフサイエンス / 分子生物学 /
ライフサイエンス / 医療薬学 /
ライフサイエンス / 生理学 /
ライフサイエンス / 神経科学一般 /

論文

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Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality

Masao Horie Kazuyuki Mekada Hiromi Sano Yoshiaki Kikkawa Satomi Chiken Takuro Someya Keisuke Saito M. Ibrahim Hossain Masaaki Nameta Kuniya Abe Kenji Sakimura Katsuhiko Ono Atsushi Nambu Atsushi Yoshiki Hirohide Takebayashi

NEUROBIOLOGY OF DISEASE 96 271-283 2016年12月 [査読有り]

We identified a novel spontaneous mutant mouse showing motor symptoms that are similar to those of the dystonia musculorum (dt) mouse. The observations suggested that the mutant mice inherited the mild dt phenotype as an autosomal recessive trait....

Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway

Kenta Kobayashi Hiromi Sano Shigeki Kato Keisuke Kuroda Shinichi Nakamuta Tadashi Isa Atsushi Nambu Kozo Kaibuchi Kazuto Kobayashi

NEUROSCIENCE LETTERS 630 45-52 2016年9月 [査読有り]

Developing cortical neurons undergo a number of sequential developmental events including neuronal survival/apoptosis, and the molecular mechanism underlying each characteristic process has been studied in detail. However, the survival pathway of ...

Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease

Hiromi Sano Miho Murata Atsushi Nambu

JOURNAL OF NEUROCHEMISTRY 134(2) 371-381 2015年7月 [査読有り]

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the loss of nigrostriatal dopaminergic neurons and consequent motor dysfunction. Zonisamide (1,2-benzisoxazole-3-methanesulfonamide), which was originally developed ...

Disruption of actin-binding domain-containing Dystonin protein causes dystonia musculorum in mice

Masao Horie Keisuke Watanabe Asim K. Bepari Jun-ichiro Nashimoto Kimi Araki Hiromi Sano Satomi Chiken Atsushi Nambu Katsuhiko Ono Kazuhiro Ikenaka Akiyoshi Kakita Ken-ichi Yamamura Hirohide Takebayashi

EUROPEAN JOURNAL OF NEUROSCIENCE 40(10) 3458-3471 2014年11月 [査読有り]

The Dystonin gene (Dst) is responsible for dystonia musculorum (dt), an inherited mouse model of hereditary neuropathy accompanied by progressive motor symptoms such as dystonia and cerebellar ataxia. Dst-a isoforms, which contain actin-binding do...

Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra

Hiromi Sano Satomi Chiken Takatoshi Hikida Kazuto Kobayashi Atsushi Nambu

Journal of Neuroscience 33(17) 7583-7594 2013年4月 [査読有り]

The striatum and subthalamic nucleus (STN) are the input stations of the basal ganglia and receive excitatory afferents from the cerebral cortex. The basal ganglia control voluntary movements through three parallel pathways mediated by the input s...

MISC

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Identification and characterization of novel dystonia musculorum mutant mice

H. Takebayashi M. Horie K. K. Mekada H. Sano Y. Kikkawa S. Chiken T. Someya K. Saito M. I. Hossain M. Nameta K. Abe K. Sakimura K. Ono A. Nambu A. Yoshiki

JOURNAL OF NEUROCHEMISTRY 142 229-229 2017年8月

新規自然発生dystonia musculorumマウスの樹立と中枢神経系についての組織学的解析

堀江正男目加田和之目加田和之佐野裕美吉川欣亮知見聡美染谷拓郎斎藤慶介イブラヒムホサインMD 行田正晃阿部訓也崎村建司小野勝彦南部篤吉木淳竹林浩秀

日本解剖学会総会・全国学術集会講演プログラム・抄録集 122nd 196 2017年

Adeno-associated virus-mediated gene transduction of taste cells in vivo

Kashio Makiko Taruno Akiyuki Sun Hongxin Kobayashi Kenta Sano Hiromi Nambu Atsushi Marunaka Yoshinori

CHEMICAL SENSES 41(9) E276-E277 2016年11月 [査読有り]

Pathophysiology and therapy for basal ganglia diseases

H. Sano S. Chiken M. Murata K. Kobayashi A. Nambu

JOURNAL OF NEUROCHEMISTRY 123 37-37 2012年10月

Striatopallidal neurons regulate motor activity through the response pattern in the external segment of globus pallidus and substantia nigra pars reticulata

Hiromi Sano Satomi Chiken Kazuto Kobayashi Atsushi Nambu