BACKGROUND: The efficacy of immune checkpoint inhibitors (ICIs) in pleural mesothelioma has recently been established. The response to ICIs can be predicted by quantitative analysis of cells and their spatial distribution in the tumor microenviron...
Interdisciplinary cardiovascular and thoracic surgery 36(3) 2023年3月
Total pleural covering is implemented to reinforce the visceral pleura with surgical sheets. It has been adopted for diffuse cystic lung diseases such as lymphangioleiomyomatosis to prevent pneumothorax and has achieved good results. The procedure...
Mineyoshi Sato   Nako Maishi   Yasuhiro Hida   Aya Yanagawa-Matsuda   Mohammad Towfik Alam   Jun Sakakibara-Konishi   Jin-Min Nam   Yasuhito Onodera   Satoshi Konno   Kyoko Hida   
Cancer medicine 2023年2月
In lung cancer, immune checkpoint inhibitors (ICIs) are often inadequate for tumor growth inhibition. Angiogenic inhibitors (AIs) are required to normalize tumor vasculature for improved immune cell infiltration. However, in clinical practice, ICI...
Masahiro Morimoto   Nako Maishi   Takuya Tsumita   Mohammad Towfik Alam   Hiroshi Kikuchi   Yasuhiro Hida   Yusuke Yoshioka   Takahiro Ochiya   Dorcas A Annan   Ryo Takeda   Yoshimasa Kitagawa   Kyoko Hida   
Frontiers in oncology 13 973871-973871 2023年
BACKGROUND: Tumor blood vessels play a key role in tumor metastasis. We have previously reported that tumor endothelial cells (TECs) exhibit abnormalities compared to normal endothelial cells. However, it is unclear how TECs acquire these abnormal...