CYTOGENETIC AND GENOME RESEARCH 108(1-3) 83-90 2004年11月 [査読有り]
Chromosome rearrangement has been considered to be important in the evolutionary process. Here, we demonstrate the evolutionary relationship of the rearranged human chromosome 12 and the corresponding chromosome XII in apes (chimpanzee, bonobo, go...
AMERICAN JOURNAL OF PRIMATOLOGY 64(3) 261-275 2004年11月 [査読有り]
The chimpanzee populations of the Bossou and Nimba regions in West Africa were genetically surveyed to 1) reveal the genetic relationship between the Bossou and Nimba populations, and 2) elucidate the evolutionary relationship between the Bossou-N...
H Ito   H Nara   M Inoue-Murayama   MK Shimada   A Koshimura   Y Ueda   H Kitagawa   Y Takeuchi   Y Mori   Y Murayama   M Morita   T Iwasaki   K Ota   Y Tanabe   S Ito   
JOURNAL OF VETERINARY MEDICAL SCIENCE 66(7) 815-820 2004年7月 [査読有り]
Various canine breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of them are under genetic control. Although dopaminergic neurotransmission system is considered t...
MK Shimada   M Inoue-Murayama   Y Ueda   M Maejima   Y Murayama   O Takenaka   Hayasaka, I   S Ito   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 316(4) 1186-1190 2004年4月 [査読有り]
The dopamine receptor D4 (DRD4) has received increasing research attention in behavioral science, psychiatry, and psychopharmacology. However, the number of available genetic markers for primates is still insufficient. We identified a novel variat...
霊長類研究 = Primate research 19(2) 145-155 2003年9月 [査読有り]
One of the primary objectives in the captive management of chimpanzees is to preserve to the greatest extent possible the genetic diversity that still exists in wild gene pools. Furthermore, it is desirable to prevent the occurrence of intersubspe...
Makoto K. Shimada   Tsunetoshi Nishida   
bioRxiv 2020年3月
<title>Abstract</title>The application of current genome-wide sequencing techniques on human populations helps elucidate the considerable gene flow among genus<italic>Homo</italic>, which includes modern and archaic humans. Gene flow among current...
数塩基の短い塩基配列の反復である、STR (Short Tandem Repeat) は反復数変化が高頻度に起こる。そこで反復数の高変異性を通じて、適応的形質や進化的安定状態を速やかに獲得したとする仮説が提唱されている。反面、ヒトの反復配列には、神経変性疾患の原因となる反復配列が複数知られている。そのような危険な複数の反復配列がなぜ人類集団に維持されているのか、良くわかっていない。我々は自分たちが構築し公開している、遺伝子データベース、H-invDBに多型情報を統合することで、ヒトゲノム中...