Makoto K. Shimada   Tsunetoshi Nishida   
MOLECULAR PHYLOGENETICS AND EVOLUTION 109 409-414 2017年4月 [査読有り]
Felsenstein's PHYLIP package of molecular phylogeny tools has been used globally since 1980. The programs are receiving renewed attention because of their character-based user interface, which has the advantage of being scriptable for use with lar...
MOLECULAR GENETICS AND GENOMICS 291(5) 1851-1869 2016年10月 [査読有り]
Short Tandem Repeats (STRs) comprise repeats of one to several base pairs. Because of the high mutability due to strand slippage during DNA synthesis, rapid evolutionary change in the number of repeating units directly shapes the range of repeat-n...
Makoto K. Shimada   Noriko Sasaki-Haraguchi   Akila Mayeda   
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16(5) 10376-10388 2015年5月 [査読有り]
According to the length distribution of human introns, there is a large population of short introns with a threshold of 65 nucleotides (nt) and a peak at 85 nt. Using human genome and transcriptome databases, we investigated the introns shorter th...
Makoto K. Shimada   Tsunetoshi Nishida   
bioRxiv 2020年3月
<title>Abstract</title>The application of current genome-wide sequencing techniques on human populations helps elucidate the considerable gene flow among genus<italic>Homo</italic>, which includes modern and archaic humans. Gene flow among current...
数塩基の短い塩基配列の反復である、STR (Short Tandem Repeat) は反復数変化が高頻度に起こる。そこで反復数の高変異性を通じて、適応的形質や進化的安定状態を速やかに獲得したとする仮説が提唱されている。反面、ヒトの反復配列には、神経変性疾患の原因となる反復配列が複数知られている。そのような危険な複数の反復配列がなぜ人類集団に維持されているのか、良くわかっていない。我々は自分たちが構築し公開している、遺伝子データベース、H-invDBに多型情報を統合することで、ヒトゲノム中...