Glutamate induces Ca2+ influx in neurons through NMDA receptors (NMDARs) and activates Ca2+-dependent protein kinases, including CaMKII, which play critical roles in synaptic plasticity and learning. However, how these kinase...
Protein phosphorylation plays critical roles in a variety of intracellular signaling pathways and physiological functions that are controlled by neurotransmitters and neuromodulators in the brain. Dysregulation of these signaling pathways has been...
For normal neurogenesis and circuit formation, delamination of differentiating neurons from the proliferative zone must be precisely controlled; however, the regulatory mechanisms underlying cell attachment are poorly understood. Here, we show tha...
<title>Abstract</title>Here we report that CyclinD1 (CCND1) directly regulates both the proliferative and immature states of cerebellar granule cell progenitors (GCPs). CCND1 not only accelerates cell cycle but also upregulates ATOH1 protein, an e...
The Journal of neuroscience : the official journal of the Society for Neuroscience 40(14) 2935-2942 2020年2月 [査読有り]
In Drosophila, dopamine signaling to the mushroom body intrinsic neurons, Kenyon cells (KCs), is critical to stabilize olfactory memory. Little is known about the downstream intracellular molecular signaling underlying memory stabilization. Here w...
Nagai, T   Nakamuta, S   Kuroda, K   Nakauchi, S   Nishioka, T   Takano, T   Zhang, X   Tsuboi, D   Funahashi, Y   Nakano, T   Yoshimoto, J   Kobayashi, K   Uchigashima, M   Watanabe, M   Miura, M   Nishi, A   Kobayashi, K   Yamada, K   Amano, M   Kaibuchi, K