Systems and Computers in Japan 38(1) 41-50 2007年1月 [査読有り]
Spike timing-dependent synaptic plasticity (STDP) develops neural circuits through close interaction with the firing function of single neurons. Here, we investigate the neuronal firing function dependency of STDP about a single-compartment Hodgki...
Sustained contraction of cells depends on sustained Rho-associated kinase (Rho-kinase) activation. We developed a computational model of the Rho-kinase pathway to understand the systems characteristics. Thrombin-dependent in vivo transient respons...
JOURNAL OF COMPUTATIONAL NEUROSCIENCE 16(3) 251-265 2004年5月 [査読有り]
Although the supralinear summation of synchronizing excitatory postsynaptic potentials (EPSPs) and backpropagating action potentials (APs) is important for spike-timing-dependent synaptic plasticity (STDP), the spatial conditions of the amplificat...
ICONIP'02: PROCEEDINGS OF THE 9TH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING 25-29 2002年 [査読有り]
In this study, we simulate pairing backpropagating action potentials (APs) with excitatory postsynaptic potentials (EPSPs) in a hippocampal CA1 model neuron, and make clear the synaptic-site dependence of the supralinear amplification, which is co...
ICONIP'02: PROCEEDINGS OF THE 9TH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING 1490-1494 2002年 [査読有り]
In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca2+ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca2+ ...