医療科学部

研究分野

ライフサイエンス / 生体医工学 /

論文

蔦村琴子大橋篤細江眞生高須立平石田大賀新典雄堀秀生井平勝川口和紀中井滋長谷川みどり坪井直毅

日本透析医学会雑誌 56(Suppl.1) 475-475 2023年5月

First‐in‐human study of blood amyloid β removal from early Alzheimer's disease patients with normal kidney function

Midori Hasegawa Nobuya Kitaguchi Hajime Takechi Kazunori Kawaguchi Kengo Ito Takashi Kato Masao Kato Norio Nii Sachie Yamada Atsushi Ohashi Shigehisa Koide Hiroki Hayashi Kazuo Takahashi Daijo Inaguma Yukio Yuzawa Naotake Tsuboi

Therapeutic Apheresis and Dialysis 26(3) 529-536 2022年6月

Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease.

Kitaguchi N Tatebe H Sakai K Kawaguchi K Matsunaga S Kitajima T Tomizawa H Kato M Sugiyama S Suzuki N Mizuno M Takechi H Nakai S Hiki Y Kushimoto H Hasegawa M Yuzawa Y Tokuda T

Journal of Alzheimer's disease : JAD 69(3) 687-707 2019年 [査読有り]

Adsorptive filtration systems for effective removal of blood amyloid β: a potential therapy for Alzheimer's disease.

Kitaguchi N Kawaguchi K Yamazaki K Kawachi H Sakata M Kaneko M Kato M Sakai K Ohashi N Hasegawa M Hiki Y Yuzawa Y

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 21(2) 220-229 2018年6月 [査読有り]

Toward the treatment for Alzheimer's disease: adsorption is primary mechanism of removing amyloid β protein with hollow-fiber dialyzers of the suitable materials, polysulfone and polymethyl methacrylate.

Kawaguchi K Saigusa A Yamada S Gotoh T Nakai S Hiki Y Hasegawa M Yuzawa Y Kitaguchi N

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 19(2) 149-158 2016年6月 [査読有り]

MISC

<2 345 6 >

Potential therapeutic system for Alzheimer's disease: removal of blood A beta s by hemodialzyers and its effect on the cognitive functions of renal-failure patients

Masao Kato Kazunori Kawaguchi Sigeru Nakai Kazutaka Murakami Hideo Hori Atsushi Ohashi Yoshiyuki Hiki Shinji Ito Yasunobu Shimano Nobuo Suzuki Satoshi Sugiyama Hiroshi Ogawa Hiroko Kusimoto Tatsuro Mutoh Yukio Yuzawa Nobuya Kitaguchi

JOURNAL OF NEURAL TRANSMISSION 119(12) 1533-1544 2012年12月

The pathological changes of Alzheimer's disease include the deposition of amyloid beta protein (A beta) as senile plaques in the brain. We hypothesized that the rapid removal of A beta s from the blood may act as a peripheral A beta drainage sink ...

維持血液透析患者におけるビタミンE被覆膜の抗酸化効果の評価

大橋篤堀秀生川口和紀中井滋北口暢哉比企能之深谷忍山下満小川忠村上和隆富田亮長谷川みどり湯澤由紀夫

日本透析医学会雑誌 45(Suppl.1) 480-480 2012年5月

血中Aβ除去によるアルツハイマー病治療システムの検討血液透析による血中Aβ変化と喫煙との関係

北口暢哉伊藤信二川口和紀村上和隆中井滋加藤政雄島野泰暢鈴木信夫堀秀生大橋篤比企能之杉山敏湯澤由紀夫武藤多津郎

Dementia Japan 25(3) 320-320 2011年10月

18ヵ月間の維持血液透析による血中Amyloid Beta-Protein(Aβ)、MMSEスコアの経時変化

川口和紀堀秀生大橋篤中井滋比企能之村上和隆湯澤由紀夫伊藤信二石田治島野泰暢武藤多津郎北口暢哉

Dementia Japan 25(3) 321-321 2011年10月

生分解性不織布デバイスによる慢性腎不全モデルラットの治療効果

堀秀生川口和紀大橋篤新里昌功森田美和長尾枝澄香北口暢哉

医工学治療 23(Suppl.) 140-140 2011年4月