The Journal of reproduction and development 64(6) 495-502 2018年12月 [査読有り]
Interferon-tau (IFNT), a type I interferon (IFN), is known as pregnancy recognition signaling molecule secreted from the ruminant conceptus during the preimplantation period. Type I IFNs, such as IFN-alpha and IFN-beta, are known to activate cell-...
Hiroki Kunii   Keisuke Koyama   Tsukino Ito   Toshiyuki Suzuki   Ahmed Z Balboula   Takahiro Shirozu   Hanako Bai   Masashi Nagano   Manabu Kawahara   Masashi Takahashi   
Journal of dairy science 101(9) 8396-8400 2018年9月 [査読有り]
In ruminants, IFN-tau (IFNT) is a pregnancy recognition signal secreted by the embryonic trophectoderm before implantation, and it induces the expression of IFN-stimulated genes (ISG) in the uterine endometrium and blood leukocytes. The expression...
In ruminants, interferon-tau (IFNT)-mediated expression of interferon-stimulated genes in peripheral blood leukocytes (PBLs) can indicate pregnancy. Recently, type 1 IFN-mediated activation of lysosomes and lysosomal cathepsins (CTSs) was observed...
The Journal of reproduction and development 63(3) 211-220 2017年6月 [査読有り]
Interferon tau (IFN-τ) is a ruminant-specific type I IFN secreted by a conceptus before its attachment to the uterus. IFN-τ induces the expression of IFN-stimulated genes (ISGs) via the type I IFN receptor (IFNAR), which is composed of IFNAR1 and ...
The Journal of reproduction and development 62(1) 29-35 2016年 [査読有り]
MX belongs to a family of type I interferon (IFN)-stimulated genes, and the MX protein has antiviral activity. MX has at least two isoforms, known as MX1 and MX2, in mammals. Moreover, bovine MX1 has been found to have alternative splice variants-...