Anna Clara M Galdino   Mylene Vaillancourt   Diana Celedonio   Kara Huse   Yohei Doi   Janet S Lee   Peter Jorth   
Nature microbiology 9(3) 631-646 2024年3月
The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified ...
Leilei Wang   Xun Zhou   Yanyan Lu   Xuefei Zhang   Jianping Jiang   Zhewei Sun   Mengyun Yin   Yohei Doi   Minggui Wang   Qinglan Guo   Fan Yang   
International journal of antimicrobial agents 107119-107119 2024年2月
OBJECTIVE: Imipenem-relebactam (IMR), a novel β-lactam/β-lactamase inhibitor combination, is recommended for infections caused by difficult-to-treat Pseudomonas aeruginosa. This study aimed to investigate the evolution trajectory of IMR resistance...
Akito Kawai   William C Shropshire   Masahiro Suzuki   Jovan Borjan   Samuel L Aitken   William C Bachman   Christi L McElheny   Micah M Bhatti   Ryan K Shields   Samuel A Shelburne   Yohei Doi   
mBio 15(2) e0287423 2024年2月
β-Lactamases can accumulate stepwise mutations that increase their resistance profiles to the latest β-lactam agents. CMY-185 is a CMY-2-like β-lactamase and was identified in an Escherichia coli clinical strain isolated from a patient who underwe...
Kevin J Westbrook   Gayatri Shankar Chilambi   Madison E Stellfox   Hayley R Nordstrom   Yanhong Li   Alina Iovleva   Niyati H Shah   Chelsea E Jones   Ellen G Kline   Kevin M Squires   William R Miller   Truc T Tran   Cesar A Arias   Yohei Doi   Ryan K Shields   Daria Van Tyne   
The Journal of antimicrobial chemotherapy 2024年2月
OBJECTIVES: To investigate the genomic diversity and β-lactam susceptibilities of Enterococcus faecalis collected from patients with infective endocarditis (IE). METHODS: We collected 60 contemporary E. faecalis isolates from definite or probable ...
Hiroshi Yotsuyanagi   Norio Ohmagari   Yohei Doi   Masaya Yamato   Nguyen Hoang Bac   Bong Ki Cha   Takumi Imamura   Takuhiro Sonoyama   Genki Ichihashi   Takao Sanaki   Yuko Tsuge   Takeki Uehara   Hiroshi Mukae   
JAMA network open 7(2) e2354991 2024年2月
IMPORTANCE: Treatment options for COVID-19 are warranted irrespective of the presence of risk factors for severe disease. OBJECTIVE: To assess the efficacy and safety of ensitrelvir in patients with mild to moderate COVID-19. DESIGN, SETTING, AND ...