研究者氏名	坪井良樹
	ツボイヨシキ
URL
所属	藤田医科大学
部署	医科学　医検　予防医科学分野研究推進ﾕﾆｯﾄ
職名	助教
学位	博士（医療科学）
科研費研究者番号	60908466
ORCID ID	0000-0001-8145-3949
J-Global ID	202101006497253995

研究キーワード

エピジェネティクス ,DNAメチル化 ,分子疫学

研究分野

ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない /

学歴

2020年4月

2023年3月

藤田医科大学保健学研究科

2016年4月

2018年3月

藤田保健衛生大学保健学研究科

2012年4月

2016年3月

藤田保健衛生大学医療科学部臨床検査学科

受賞

2021年12月

第80回日本公衆衛生学会総会, 優秀演題賞

論文

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Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: A long-term cohort study.

Yoshiki Tsuboi Hiroya Yamada Eiji Munetsuna Ryosuke Fujii Mirai Yamazaki Yoshitaka Ando Genki Mizuno Yuji Hattori Hiroaki Ishikawa Koji Ohashi Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki

Cancer epidemiology 78 102162-102162 2022年6月

BACKGROUND: Smoking is well known to be a major risk factor for cancer, and to decrease the levels of aryl hydrocarbon receptor repressor (AHRR) DNA methylation. AHRR is a key regulator for AHR signaling, which is involved in chemical metabolism a...

Association of drinking behaviors with TXNIP DNA methylation levels in leukocytes among the general Japanese population.

Keisuke Maeda Hiroya Yamada Eiji Munetsuna Ryosuke Fujii Mirai Yamazaki Yoshitaka Ando Genki Mizuno Hiroaki Ishikawa Koji Ohashi Yoshiki Tsuboi Yuji Hattori Yuya Ishihara Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki

The American journal of drug and alcohol abuse 48(3) 1-9 2022年4月

Background: Thioredoxin-interacting protein (TXNIP) controls the cellular redox balance by binding to and inhibiting the expression and function of thioredoxin. DNA methylation of the TXNIP gene is involved in the regulation of TXNIP mRNA expressi...

Increased brain-derived neurotrophic factor in the serum of persons with nonalcoholic fatty liver disease.

Yuji Hattori Hiroya Yamada Eiji Munetsuna Yoshitaka Ando Genki Mizuno Ryosuke Fujii Yoshiki Tsuboi Naohiro Ichino Keisuke Osakabe Keiko Sugimoto Hiroaki Ishikawa Koji Ohashi Koji Suzuki

Endocrine journal 69(8) 999-1006 2022年3月

The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) is a global health problem. In recent years, the inhibitory effect of brain-derived neurotrophic factor (BDNF) on diabetes mellitus and fatty liver has been clarified. The purpo...

DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population.

Mirai Yamazaki Hiroya Yamada Eiji Munetsuna Keisuke Maeda Yoshitaka Ando Genki Mizuno Ryosuke Fujii Yoshiki Tsuboi Koji Ohashi Hiroaki Ishikawa Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki

Endocrine journal 69(3) 319-326 2022年3月

Metabolic syndrome (MetS) is cluster of metabolic diseases, including abdominal obesity, hyperglycemia, high blood pressure, and dyslipidemia, that directly escalate the risk of type 2 diabetes, heart disease, and stroke. Thioredoxin-interacting p...

Prediction of overall survival in patients with pancreatic ductal adenocarcinoma: histogram analysis of ADC value and correlation with pathological intratumoral necrosis.

Yoshifumi Noda Hiroyuki Tomita Takuma Ishihara Yoshiki Tsuboi Nobuyuki Kawai Masaya Kawaguchi Tetsuro Kaga Fuminori Hyodo Akira Hara Avinash R Kambadakone Masayuki Matsuo

BMC medical imaging 22(1) 23-23 2022年2月

BACKGROUND: To evaluate the utility of histogram analysis (HA) of apparent diffusion coefficient (ADC) values to predict the overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC) and to correlate with pathologically evalua...