The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host(1-5). Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonel...
Yuko Naito-Matsui   Leela R. L. Davies   Hiromu Takematsu   Hsun-Hua Chou   Pam Tangvoranuntakul   Aaron F. Carlin   Andrea Verhagen   Charles J. Heyser   Seung-Wan Yoo   Biswa Choudhury   James C. Paton   Adrienne W. Paton   Nissi M. Varki   Ronald L. Schnaar   Ajit Varki   
JOURNAL OF BIOLOGICAL CHEMISTRY 292(7) 2557-2570 2017年2月 [査読有り]
All vertebrate cell surfaces display a dense glycan layer often terminated with sialic acids, which have multiple functions due to their location and diverse modifications. The major sialic acids in most mammalian tissues are N-acetylneuraminic ac...
JOURNAL OF BIOLOGICAL CHEMISTRY 292(3) 1029-+ 2017年1月 [査読有り]
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has been extensively studied,...
MOLECULAR BIOLOGY OF THE CELL 27(13) 2037-2050 2016年7月 [査読有り]
Endomitosis is a special type of mitosis in which only cytokinesis-the final step of the cell division cycle-is defective, resulting in polyploid cells. Although endomitosis is biologically important, its regulatory aspects remain elusive. Psychos...
Methods in Molecular Biology 1200 379-387 2014年 [査読有り]
Remodeling of glycans on the cell surface is an essential technique to analyze cellular function of lectin-glycan ligand interaction. Here we describe the methods to identify the responsible enzyme (glycosyltransferase) regulating the expression o...